| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
The project examined the mechanism for the onset of septic acute kidney injury (AKI). The study explored that the pattern-recognition receptors in the proximal tubules plays essential roles for the early-phase changes of lipopolysaccharide-induced AKI. Triggering this mechanism induced early-phase AKI; however, it works as a compensatory protective factor against the further progression of AKI that is induced mainly by hemodynamic changes, including glomerular filtration decline. Monocyte/macrophage showed a contribution to the early phase AKI and the effect was either protective or deteriorative; active phagocyte population protected kidney against lipopolysaccharide-induced AKI, and monocytes/macrophage with poor phagocytic activity made AKI more severe.
|
