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Role of TP signaling in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model

Research Project

Project/Area Number 15K08241
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionKitasato University

Principal Investigator

Hosono Kanako  北里大学, 医学部, 非常勤講師 (80532556)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsリンパ管新生 / TP受容体 / 慢性炎症 / ノックアウトマウス
Outline of Final Research Achievements

Lymphatic vessels in diaphragm are essential for draining the inflammatory fluid during peritonitis. In this study, we evaluated role of thromboxane A2 receptor (TP) signaling in enhancement of lymphangiogenesis in peritonitis. Peritonitis was induced by injections of LPS (25μg/mouse) into peritoneal cavities in male C57BL/6 mice. We evaluated lymphatic microvessel density in whole-mounted diaphragm tissues. A week after LPS application, expressions of COX-2, thromboxane synthase (TXS) and VEGF-C/D in diaphragm were up-regulated with increment of lymphangiogenesis, and lymphangiogenesis and the expressions of VEGF-C/D were suppressed in TP KO mice. CD3ε positive cells and CD11b positive cells expressing VEGF-C/D were accumulated in diaphragm in a TP-dependent manner. These results indicated that lymphangiogenesis in diaphragm is up-regulated by TX-TP signaling via induction of VEGF-C/D, suggesting TP signaling as a potential therapeutic target.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (17 results)

All 2017 2016 2015 Other

All Journal Article (7 results) (of which Open Access: 5 results,  Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Invited: 2 results) Book (2 results) Remarks (2 results)

  • [Journal Article] 特集 血管制御系と疾患 生理活性脂質と脈管新生2017

    • Author(s)
      馬嶋正隆、天野英樹、細野加奈子、伊藤義也
    • Journal Title

      生体の科学

      Volume: 68 Issue: 4 Pages: 304-308

    • DOI

      10.11477/mf.2425200634

    • ISSN
      0370-9531, 1883-5503
    • Year and Date
      2017-08-15
    • Related Report
      2017 Annual Research Report
    • Open Access
  • [Journal Article] Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice.2016

    • Author(s)
      Hosono K, Isonaka R, Kawakami T, Narumiya S, Majima M.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 10 Pages: e0162532-e0162532

    • DOI

      10.1371/journal.pone.0162532

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Vascular endothelial growth factor receptor type 1 signaling prevents delayed wound healing in diabetes by attenuating the production of IL-1β by recruited macrophages.2016

    • Author(s)
      Okizaki S, Ito Y, Hosono K, Oba K, Ohkubo H, Kojo K, Nishizawa N, Shibuya M, Majima M.
    • Journal Title

      Am J Pathol

      Volume: 186(6) Pages: 1481-1498

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model.2015

    • Author(s)
      Matsuda H, Hosono K, Tsuru S, Kurashige C, Sekiguchi K, Akira S, Uematsu S, Okamoto H, Majima M.
    • Journal Title

      Life Sci.

      Volume: 142 Pages: 1-7

    • DOI

      10.1016/j.lfs.2015.10.008

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Thromboxane A2 induces blood flow recovery via platelet adhesion to ischaemic regions.2015

    • Author(s)
      Amano H, Ito Y, Eshima K, Kato S, Ogawa F, Hosono K, Oba K, Tamaki H, Sakagami H, Shibuya M, Narumiya S, Majima M.
    • Journal Title

      Cardiovasc Res.

      Volume: 107 Issue: 4 Pages: 509-521

    • DOI

      10.1093/cvr/cvv139

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] プロスタグランジンによるリンパ管新生とリンパ組織可塑性の制御2015

    • Author(s)
      馬嶋正隆、細野加奈子
    • Journal Title

      医学のあゆみ

      Volume: 254 Pages: 1109-1114

    • Related Report
      2015 Research-status Report
  • [Journal Article] 病態時のリンパ管新生、リンパ組織の可塑性を制御するプロスタノイドの役割2015

    • Author(s)
      馬嶋正隆、天野英樹、細野加奈子
    • Journal Title

      細胞

      Volume: 47 Pages: 20-23

    • Related Report
      2015 Research-status Report
  • [Presentation] 病態時のリンパ管新生を制御する脂質メディエーターの役割2017

    • Author(s)
      細野加奈子、松田弘美、馬嶋正隆
    • Organizer
      第41回日本リンパ学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リンパ管・リンパ組織の可塑性を制御する生理活性脂質の役割2016

    • Author(s)
      馬嶋正隆、天野英樹、細野加奈子
    • Organizer
      第40回日本リンパ学会総会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2016-06-24
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] エンドトキシン誘発腹膜炎マウスの横隔膜リンパ管新生を増強するトロンンボキサン受容体シグナリングの役割2016

    • Author(s)
      松田弘美,細野加奈子,馬嶋正隆
    • Organizer
      第40回日本リンパ学会総会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2016-06-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Roles of Prostaglandins in regulation of plasticity of lymphatics and lymph nodes2016

    • Author(s)
      Majima Masataka, Hosono Kanako, Amano Hideki, Fujita Tomoe
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Role of TP signaling in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model2016

    • Author(s)
      Matsuda Hiromi, Hosono Kanako, Tsuru Seri, Narumiya Shuh, Majima Masataka
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Signaling of prostaglandin E receptors, EP3 and EP4 facilitates wound healing and lymphangiogenesis with enhanced recruitment of CD11b+ macrophages in mice2016

    • Author(s)
      Hosono Kanako, Isonaka Risa , Kawakami Tadashi, Narumiya Shuh, Majima Masataka
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Book] 実験医学2017

    • Author(s)
      馬嶋正隆、天野英樹、細野加奈子
    • Total Pages
      7
    • Publisher
      洋土社
    • Related Report
      2016 Research-status Report
  • [Book] 炎症と免疫2016

    • Author(s)
      馬嶋正隆、天野英樹、細野加奈子
    • Total Pages
      10
    • Publisher
      先端医学社
    • Related Report
      2016 Research-status Report
  • [Remarks] 北里大学医学部薬理学 大学院医療系研究科分子薬理学

    • URL

      http://www.med.kitasato-u.ac.jp/pharm/index.html

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Remarks] 北里大学医学部薬理学 大学院医療系研究科分子薬理学

    • URL

      http://www.med.kitasato-u.ac.jp/pharm/index.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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