micro RNA as the master key for protection of oxidative stress
| Project/Area Number |
15K08244
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
青山 晃治 帝京大学, 医学部, 准教授 (00420943)
押鐘 浩之 帝京大学, 医学部, 助教 (10727283)
松村 暢子 帝京大学, 医学部, 助教 (30317698)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | グルタチオン / EAAC1 / GTRAP3-18 / microRNA / タウリン / システイン / GTRAP / glutathione / micro RNA-96-5p / microRNA-96-5p |
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| Outline of Final Research Achievements |
Our preliminary studies indicated GTRAP and EAAC1 are inversely regulated by miR96, but there is no miR96-binding site on GTRAP messenger RNA. We speculated the inhibition by miR96 is not achieved by a direct binding to GTRAP but is mediated through another unidentified protein. This protein has been identified by this project.
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Report
(4 results)
Research Products
(5 results)
