Mechanisms for the manifestation of intracellular calcium dependent automaticity in the pulmonary-vein myocardium
| Project/Area Number |
15K08247
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肺静脈心筋 / 活動電位 / 細胞内カルシウム / 心房細動 / ナトリウムチャネル / 自動能 / カリウム電流 / ナトリウム・カルシウム交換機構 / アドレナリン受容体 / 伸展 / 動静脈瘻 / 伸展活性化チャネル |
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| Outline of Final Research Achievements |
Factors involved in the manifestation of the intracellular Ca2+-dependent automaticity were examined in pulmonary vein myocardium of guinea pigs, rats and mice. Acute and chronic stretch to the pulmonary vein enhanced the automatic activity through activation of stretch-activated ion channels. Alpha- and beta-adrenoceptor stimulation manifested the automaticity and pacemaker depolarization through enhancement of the Na+/Ca2+ exchanger, and the Ca2+ current and persistent Na+ current, respectively. Blockade of these ionic mechanisms was shown to be effective for the supression of pulmonary vein automaticity and probably atrial fibrillation.
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Report
(4 results)
Research Products
(75 results)
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[Journal Article] Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway.2017
Author(s)
Huiling Jin, Takayuki Fujita, Meihua Jin, Reiko Kurotani, Iyuki Namekata, Shogo Hamaguchi, Yuko Hidaka, Wenqian Cai, Kenji Suita, Yoshiki Ohnuki, Yasumasa Mototani, Kouichi Shiozawa, Rajesh Prajapati, Chen Liang, Masanari Umemura, Utako Yokoyama, Motohiko Sato, Hikaru Tanaka, Satoshi Okumura, Yoshihiro Ishikawa.
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Journal Title
J Mol Cell Cardiol.
Volume: 108
Pages: 170-180
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Haruna Kanae, Shogo Hamaguchi, Yumi Wakasugi, Taichi Kusakabe, Keisuke Kato, Iyuki Namekata, Hikaru Tanaka. Pathological prolongation of action potential duration as a cause of the reduced alpha-adrenoceptor-mediated negative inotropy in streptozotocin-induced diabetic mice myocardium.2017
Author(s)
Haruna Kanae, Shogo Hamaguchi, Yumi Wakasugi, Taichi Kusakabe, Keisuke Kato, Iyuki Namekata, Hikaru Tanaka.
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Journal Title
J Pharmacol Sci.
Volume: 135（3）
Issue: 3
Pages: 131-133
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Manifestation of automaticity in the pulmonary vein myocardium of rats with abdominal aorto-venocaval shunt.2015
Author(s)
Shogo Hamaguchi, Yayoi Tsuneoka, Ayumi Tanaka, Masahiko Irie, Masato Tsuruta, Takahiro Nakayama, Iyuki Namekata, Mizuki Nada, Megumi Aimoto, Akira Takahara, Hikaru Tanaka.
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Journal Title
J. Pharmacol. Sci.
Volume: 128
Issue: 4
Pages: 212-215
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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