| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Factors involved in the manifestation of the intracellular Ca2+-dependent automaticity were examined in pulmonary vein myocardium of guinea pigs, rats and mice. Acute and chronic stretch to the pulmonary vein enhanced the automatic activity through activation of stretch-activated ion channels. Alpha- and beta-adrenoceptor stimulation manifested the automaticity and pacemaker depolarization through enhancement of the Na+/Ca2+ exchanger, and the Ca2+ current and persistent Na+ current, respectively. Blockade of these ionic mechanisms was shown to be effective for the supression of pulmonary vein automaticity and probably atrial fibrillation.
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