Regulation of ischemic organ injury by endothelin and estrogen and sex difference
| Project/Area Number |
15K08252
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
Ohkita Mamoru 大阪薬科大学, 薬学部, 准教授(移行) (60449824)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | エンドセリン / エストロゲン / 性差 |
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| Outline of Final Research Achievements |
There are significant sex difference in ischemic acute kidney injury (AKI). A selective endothelin (ET) A receptor antagonist showed renoprotective effects in male but not female AKI rats. In addition, there was a clear difference in the effects of selective ETA receptor antagonist depending on the presence or absence of female sex hormones, suggesting that ET-1/ETA receptor system is closely involved in the pathogenesis of AKI and sex difference in AKI. Furthermore, from the studies using ETB receptor-deficient rats, it became clear that ETB receptor also plays an important role in gender difference of AKI.
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Report
(4 results)
Research Products
(4 results)
