Research for homeodynamics regeneration-promoting drug discovery
| Project/Area Number |
15K08253
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kindai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
劉 克約 岡山大学, 医歯薬学総合研究科, 非常勤研究員 (40432637)
西堀 正洋 岡山大学, 医歯薬学総合研究科, 教授 (50135943)
丹羽 淳子 近畿大学, 医学部, 講師 (60122082)
小堀 宅郎 近畿大学, 医学部, 助教 (60734697)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ホメオダイナミクス / 組織修復機構 / 血管内皮細胞 / HMGB1 / マクロファージ / マクローファージ分化 / 血管新生 / 骨髄ニッチ / マクロファージ分化 |
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| Outline of Final Research Achievements |
Homeodynamics is one of the fundamental life phenomena in the fields of neurology, immunology, endocrinology, tissue repair and stem cells. During homeodynamics, the differentiation and activation of macrophages is involved in impairment of endothelium and angiogenesis. Damage-associated molecular patterns (DAMPs) are thought to play roles in the homeodynamics. Among DAMPs, interleukin(IL)-18 and advanced glycation end product(AGE) as well as high mobility group box protein1 (HMGB1) promote the differentiation and activation of macrophages.Especially, HMGB1, a ubiquitous chromatin component, is released by necrotic cells, apoptotic cells, and cells in profound distress. HMGB1 plays a critical role as a proinflammatory mediator. HMGB1 represents an important new target for drug development in a variety of inflammatory disorders, including stroke, brain injury, arteriosclerosis, and cancer.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis.2018
Author(s)
Kobori T, Hamasaki S, Kitaura A, Yamazaki Y, Nishinaka T, Niwa A, Nakao S, Wake H, Mori S, Yoshino T, Nishibori M, Takahashi H
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Journal Title
Frontiers in Immunology
Volume: 9
Pages: 334-334
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Anti-high mobility group box-1 (HMGB1) antibody attenuates delayed cerebral vasospasm and brain injury after subarachnoid hemorrhage in rats2016
Author(s)
Haruma J, Teshigawara K, Hishikawa T, Wang D, Liu K, Wake H, Mori S, Takahashi HK, Sugiu K, Date I, Nishibori M.
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Journal Title
Scientific reports
Volume: 6
Issue: 1
Pages: 37755-37768
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Histidine-rich glycoprotein prevents septic lethality through regulation of immunothrombosis and inflammation.2016
Author(s)
Wake H, Mori S, Liu K, Morioka Y, Teshigawara K, Sakaguchi M, Kuroda K, Gao Y, Takahashi H, Ohtsuka A, Yoshino T, Morimatsu H, Nishibori M.
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Journal Title
EBioMedicine
Volume: 9
Pages: 180-194
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Anti-high mobility group box 1 monoclonal antibody improves ischemia/reperfusion injury and mode of liver regeneration after partial hepatectomy.2016
Author(s)
Sugihara M, Sadamori H, Nishibori M, Sato Y, Tazawa H, Shinoura S, Umeda Y, Yoshida R, Nobuoka D, Utsumi M, Ohno K, Nagasaka T, Yoshino T, Takahashi HK, Yagi T, Fujiwara T.
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Journal Title
American Journal of Surgery
Volume: 211
Issue: 1
Pages: 179-188
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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