| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The development of Parkinson’s disease (PD) involves the degeneration of dopaminergic neurons caused by oxidative stress. The present study investigated the effects of uric acid on behavioral abnormalities in the development of PD. We used unilateral 6-hydroxydopamine (6-OHDA)-lesioned mice, which were fed on a diet with 1% uric acid and 2.5% potassium oxonate to induce hyperuricemia. The 6-OHDA-lesioned mice showed the impaired rotarod performance and the increased apomorphine-induced contralateral rotations. These behavioral abnormalities were significantly reversed by feeding with a uric acid diet for 1 week before and 5 weeks after surgery (subchronic hyperuricemia). These behavioral improvements occurred in parallel with recovery of tyrosine hydroxylase protein levels in the lesioned striatal side. The present study confirms that uric acid exerts a neuroprotective effect on dopaminergic neuronal loss, improving motor dysfunction and ameliorating PD development.
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