| Project/Area Number |
15K08259
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka City University (2016-2017)
Gunma University (2015) |
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Principal Investigator |
Oikawa Daisuke 大阪市立大学, 大学院医学研究科, 講師 (20455330)
|
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| Co-Investigator(Kenkyū-buntansha) |
徳永 文稔 大阪市立大学, 大学院医学研究科, 教授 (00212069)
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| Co-Investigator(Renkei-kenkyūsha) |
SAWASAKI Tatsuya 愛媛大学, プロテオサイエンスセンター, 教授 (50314969)
|
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | LRBA / IFN経路 |
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| Outline of Final Research Achievements |
LRBA gene codes a 320 kDa, BEACH (Beige and Chediak-Higashi) family protein, and reported as a CVID (common variable immunodeficiency) related gene. Here, we focused on the regulation of IFN pathway by the LRBA, and identified that the LRBA negatively regulates poly I:C or SeV mediated IFN-activation. Also, we identified several LRBA-binding proteins to reveal its regulating mechanism. Further studies would be needed to publish these new insight.
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