Regulation of cellular signal transduction by novel immunological factor
| Project/Area Number |
15K08259
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka City University (2016-2017)
Gunma University (2015) |
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Principal Investigator |
Oikawa Daisuke 大阪市立大学, 大学院医学研究科, 講師 (20455330)
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| Co-Investigator(Kenkyū-buntansha) |
徳永 文稔 大阪市立大学, 大学院医学研究科, 教授 (00212069)
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| Co-Investigator(Renkei-kenkyūsha) |
SAWASAKI Tatsuya 愛媛大学, プロテオサイエンスセンター, 教授 (50314969)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | LRBA / IFN経路 |
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| Outline of Final Research Achievements |
LRBA gene codes a 320 kDa, BEACH (Beige and Chediak-Higashi) family protein, and reported as a CVID (common variable immunodeficiency) related gene. Here, we focused on the regulation of IFN pathway by the LRBA, and identified that the LRBA negatively regulates poly I:C or SeV mediated IFN-activation. Also, we identified several LRBA-binding proteins to reveal its regulating mechanism. Further studies would be needed to publish these new insight.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] In-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.2018
Author(s)
Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki S, Wakamatsu K, Tokunaga F, Shimizu A.
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Journal Title
J Dermatol Sci.
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.2016
Author(s)
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, and Tokunaga F.
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Journal Title
Nat. Commun.
Volume: 7
Issue: 1
Pages: 12547-12547
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity2015
Author(s)
Sato, Y., Goto, E., Shibata, Y., Kubota, Y., Yamagata, A., Goto-Ito, S., Kubota, K., Inoue, J., Takekawa, M., Tokunaga, F. and Fukai, S.
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Journal Title
Nat. Struct. Mol. Biol.
Volume: 22
Issue: 3
Pages: 222-229
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.2015
Author(s)
Matsunaga Y, Nakatsu Y, Fukushima T, Okubo H, Iwashita M, Sakoda H, Fujishiro M, Yamamotoya T, Kushiyama A, Takahashi S, Tsuchiya Y, Kamata H, Tokunaga F, Iwai K, Asano T.
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Journal Title
Mediators Inflamm.
Volume: 2015
Issue: 1
Pages: 125380-125380
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3.2015
Author(s)
Kumanomidou T, Nishio K, Takagi K, Nakagawa T, Suzuki A, Yamane T, Tokunaga F, Iwai K, Murakami A, Yoshida Y, Tanaka K, Mizushima T.
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Journal Title
PLoS One.
Volume: 10
Issue: 10
Pages: e0140366-e0140366
DOI
Related Report
Peer Reviewed / Open Access
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