| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We have identified that CREB becomes activated during prolonged phase of hypoxia. In this study, we aimed to understand how CREB regulates its target genes specifically under the prolonged hypoxic condition. I first compared control and CREB-KD cells, and identified a gene set which is specifically induced during prolonged phase of hypoxia. GO analysis of the gene set revealed many gene groups which are involved in malignant transformation of cancer. Finally, lung metastasis was highly inhibited in CREB-KD cells, indicating that CREB activation is involved in tumor metastasis.
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