Functional analysis of epigenetic regulators in cancer development identified by retroviral insertional mutagenesis
Project/Area Number |
15K08263
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General medical chemistry
|
Research Institution | Kanazawa University |
Principal Investigator |
Suzuki Takeshi 金沢大学, がん進展制御研究所, 教授 (30262075)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | がん遺伝子 / エピジェネティクス / 非コードRNA / レトロウイルス / 挿入変異 / 疾患モデルマウス / がん分子標的 |
Outline of Final Research Achievements |
Retroviral insertional mutagenesis in mice is one of the powerful strategies for high-throughput identification of novel cancer genes. Using this system, we have frequently identified the genes encoding the enzymes engaged in histone methylation. We discovered that many of the enzymes are involved not only in the tumor initiation but also in the tumor progression such as cell invasion, epithelial mesenchymal transition and maintenance of stem cell properties. Furthermore, we found that long noncoding RNAs played a crucial role in the regulation of these epigenetic enzymes during malignant progression.
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Report
(4 results)
Research Products
(29 results)