| Project/Area Number |
15K08264
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田中 直樹 信州大学, 学術研究院医学系, 准教授 (80419374)
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| Co-Investigator(Renkei-kenkyūsha) |
AOYAMA Toshifumi 信州大学, 学術研究院医学系, 教授 (50231105)
KAMIJO Yuji 信州大学, 学術研究院医学系(医学部附属病院), 准教授 (50377636)
NAKAMURA Kozo 信州大学, 学術研究院農学系, 准教授 (20345763)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | スルファチド / 酸化ストレス / 生体分子 / PPARα |
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| Outline of Final Research Achievements |
In previous studies in human patients and mice, we have found that expression of the sulfated glycolipids sulfatides is negatively correlated with the level of oxidative stress. In the present study, we examined the influence of oxidative stress on the expression and metabolism of sulfatides. We treated cultured cell lines with several concentrations of hydrogen peroxides for 24h. The treatment with high concentration of hydrogen peroxides resulted in significant reduction of sulfatide contents. This indicates that oxidative stress directly affects the expression of sulfatides, and that the powerful stress down-regulates it. On the other hand, treatment with the low concentration tended to increase the content of sulfatides. Since several studies have suggested the importance of sulfatide expression in the growth and survival of cells, this change may be involved in the defensive response against oxidative stress.
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