The function of a novel membrane protein in renal proximal tubules

• Project/Area Number: 15K08274
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Nara Medical University (2017); Osaka University (2015-2016)
• Principal Investigator: Nagamori Shushi 奈良県立医科大学, 医学部, 教授 (90467572)
• Co-Investigator(Kenkyū-buntansha): 大垣 隆一 大阪大学, 医学系研究科, 助教 (20467525) ; 奥田 傑 大阪大学, 医学系研究科, 助教 (50511846)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 膜輸送複合体 / プロテオミクス / メタボロミクス / 腎臓 / トランスポーター / マルチオミクス / 腎近位尿細管 / 糖 / アミノ酸

Outline of Final Research Achievements

A gene, named TRAP, was identified because the expression changes are correlated with expression changes of many transporters in proximal renal tubules and encodes a novel membrane protein expressed specifically in apical membranes of the renal proximal tubules. The TRAP knockout mice showed increasing of urinary excretion of sugar, amino acids etc., which is similar to Fanconi syndrome. We showed that TRAP makes complexes with various transporters and the whole proteome of the luminal membrane transporters interacting with TRAP. In addition, by using a multi-omics approach combined comprehensive quantitative proteomics and metabolomics, it is strongly indicated that TRAP is a key molecule that integrally regulates the localization of transporters on the apical membranes of the proximal tubules.

Research Products

• [Int'l Joint Research] IRB/バルセロナ大学(スペイン)
• [Int'l Joint Research] コロンビア大学(米国)
• [Int'l Joint Research] IRB Barcelona/CIBERER/Universitat de Barcelona(Spain)
• [Journal Article] Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex (2018)
  • Author(s): Liang Weng , Yi-Peng Han, Atsushi Enomoto, Yasuyuki Kitaura, Shushi Nagamori, Yoshikatsu Kanai, Naoya Asai, Jian An, Maki Takagishi, Masato Asai, Shinji Mii, Takashi Masuko, Yoshiharu Shimomura, Masahide Takahashi.
  • Journal Title: PLoS Biology Volume: 16 Issue: 3 Pages: e2005090-e2005090
  • DOI: 10.1371/journal.pbio.2005090
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ratiometric fluorescence imaging of cell surface pH by poly(ethylene glycol)-phospholipid conjugated with fluorescein isothiocyanate (2017)
  • Author(s): Ryuichi Ohgaki, Yuji Teramura, Daichi Hayashi, Suguru Okuda, Shushi Nagamori, Madoka Taka and Yoshikatsu Kanai
  • Journal Title: Sci Res Volume: 7 Issue: 1 Pages: 17484-17484
  • DOI: 10.1038/s41598-017-17459-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells. (2017)
  • Author(s): Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, Takeda K.
  • Journal Title: Cell Reports Volume: 21 Issue: 7 Pages: 1824-1838
  • DOI: 10.1016/j.celrep.2017.10.082
  • Peer Reviewed / Open Access
• [Journal Article] Impairment of the carnitine/organic cation transporter 1?ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease (2017)
  • Author(s): Shinozaki Yasuyuki、Furuichi Kengo、Toyama Tadashi、Kitajima Shinji、Hara Akinori、Iwata Yasunori、Sakai Norihiko、Shimizu Miho、Kaneko Shuichi、Isozumi Noriyoshi、Nagamori Shushi、Kanai Yoshikatsu、Sugiura Tomoko、Kato Yukio、Wada Takashi
  • Journal Title: Kidney Int Volume: 92 Issue: 6 Pages: 1356-1369
  • DOI: 10.1016/j.kint.2017.04.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical Significance and Phenotype of MTA1 Expression in Esophageal Squamous Cell Carcinoma (2017)
  • Author(s): Honjo H, Toh Y, Sohda M, Suzuki S, Kaira K, Kanai Y, Nagamori S, Oyama T, Yokobori T, Miyazaki T, Kuwano H
  • Journal Title: Anticancer research Volume: 37 Issue: 8 Pages: 4147-4155
  • DOI: 10.21873/anticanres.11802
  • Peer Reviewed
• [Journal Article] (18)F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with (18)F-FDG and (11)C-Methionine PET. (2017)
  • Author(s): Watabe T, Ikeda H, Nagamori S, Wiriyasermkul P, Tanaka Y, Naka S, Kanai Y, Hagiwara K, Aoki M, Shimosegawa E, Kanai Y, Hatazawa J.
  • Journal Title: Eur J Nucl Med Mol Imaging. Volume: 44 Issue: 2 Pages: 321-331
  • DOI: 10.1007/s00259-016-3487-1
  • Peer Reviewed
• [Journal Article] Utilization of Liver Microsomes to Estimate Hepatic Intrinsic Clearance of Monoamine Oxidase Substrate Drugs in Humans. (2017)
  • Author(s): Masuo Y, Nagamori S, Hasegawa A, Hayashi K, Isozumi N, Nakamichi N, Kanai Y, Kato Y.
  • Journal Title: Pharm Res Volume: 印刷中 Issue: 6 Pages: 1233-1243
  • DOI: 10.1007/s11095-017-2140-4
  • NAID: 120006306246
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Essential roles of L-type amino acid transporter 1 in syncytiotrophoblast development by presenting fusogenic 4F2hc. (2017)
  • Author(s): Ohgaki R, Ohmori T, Hara S, Nakagomi S, Kanai-Azuma M, Kaneda-Nakashima K, Okuda S, Nagamori S, Kanai Y.
  • Journal Title: Mol Cell Biol. Volume: 印刷中 Issue: 11
  • DOI: 10.1128/mcb.00427-16
  • Peer Reviewed / Open Access
• [Journal Article] Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1). (2017)
  • Author(s): Kongpracha P, Nagamori S, Wiriyasermkul P, Tanaka Y, Kaneda K, Okuda S, Ohgaki R, Kanai Y.
  • Journal Title: J Pharmacol Sci. Volume: 133 Issue: 2 Pages: 96-102
  • DOI: 10.1016/j.jphs.2017.01.006
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Increased Dynamics of Tricarboxylic Acid Cycle and Glutamate Synthesis in Obese Adipose Tissue: IN VIVO METABOLIC TURNOVER ANALYSIS. (2017)
  • Author(s): Nagao H, Nishizawa H, Bamba T, Nakayama Y, Isozumi N, Nagamori S, Kanai Y, Tanaka Y, Kita S, Fukuda S, Funahashi T, Maeda N, Fukusaki E, Shimomura I.
  • Journal Title: J Biol Chem. Volume: 292 Issue: 11 Pages: 4469-4483
  • DOI: 10.1074/jbc.m116.770172
  • Peer Reviewed / Open Access
• [Journal Article] Expression of a human NPT1/SLC17A1 missense variant which increases urate export. (2016)
  • Author(s): Sakiyama M, Matsuo H, Nagamori S, Ling W, Kawamura Y, Nakayama A, Higashino T, Chiba T, Ichida K, Kanai Y, Shinomiya N.
  • Journal Title: Nucleosides Nucleotides Nucleic Acids. Volume: 35 Pages: 536-542
  • Peer Reviewed
• [Journal Article] Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. (2016)
  • Author(s): Ohshima Y, Kaira K, Yamaguchi A, Oriuchi N, Tominaga H, Nagamori S, Kanai Y, Yokobori T, Miyazaki T, Asao T, Tsushima Y, Kuwano H, Ishioka NS.
  • Journal Title: Cancer Sci. Volume: 107 Issue: 10 Pages: 1499-1505
  • DOI: 10.1111/cas.13021
  • Peer Reviewed / Open Access
• [Journal Article] Core-fucosylation plays a pivotal role in hepatitis B pseudo virus infection: a possible implication for HBV glycotherapy. (2016)
  • Author(s): Takamatsu S, Shimomura M, Kamada Y, Maeda H, Sobajima T, Hikita H, Iijima M, Okamoto Y, Misaki R, Fujiyama K, Nagamori S, Kanai Y, Takehara T, Ueda K, Kuroda S, Miyoshi E.
  • Journal Title: Glycobiology. Volume: 26 Pages: 1180-1189
  • DOI: 10.1093/glycob/cww067
  • Peer Reviewed
• [Journal Article] Interaction of the Sodium/Glucose Cotransporter (SGLT) 2 inhibitor Canagliflozin with SGLT1 and SGLT2: Inhibition kinetics, sidedness of action, and transporter-associated incorporation accounting for its pharmacodynamic and pharmacokinetic features. (2016)
  • Author(s): Ohgaki R, Wei L, Yamada K, Hara T, Kuriyama C, Okuda S, Ueta K, Shiotani M, Nagamori S, Kanai Y.
  • Journal Title: J Pharmacol Exp Ther. Volume: 358 Issue: 1 Pages: 94-102
  • DOI: 10.1124/jpet.116.232025
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling. (2016)
  • Author(s): Nagamori S, Wiriyasermkul P, Okuda S, Kojima N, Hari Y, Kiyonaka S, Mori Y, Tominaga H, Ohgaki R, Kanai Y.
  • Journal Title: Amino Acids. Volume: 48 Issue: 4 Pages: 279-286
  • DOI: 10.1007/s00726-015-2158-z
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Specific transport of 3-fluoro-l-α-methyl-tyrosine by LAT1 explains its specificity to malignant tumors in imaging. (2016)
  • Author(s): Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, Kaira K, Oriuchi N, Nagamori S, Kanai Y.
  • Journal Title: Cancer Sci. Volume: 107 Issue: 3 Pages: 347-352
  • DOI: 10.1111/cas.12878
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinicopathological significance of LAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma. (2016)
  • Author(s): Honjo H, Kaira K, Miyazaki T, Yokobori T, Kanai Y, Nagamori S, Oyama T, Asao T, Kuwano H.
  • Journal Title: J Surg Oncol. Volume: 113 Issue: 4 Pages: 381-9
  • DOI: 10.1002/jso.24160
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Transport of 3-fluoro-l-α-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [(18)F]FAMT positron emission tomography. (2016)
  • Author(s): Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, Kaira K, Kato Y, Oriuchi N, Nagamori S, Kanai Y.
  • Journal Title: J Pharmacol Sci. Volume: 130 Issue: 2 Pages: 101-109
  • DOI: 10.1016/j.jphs.2016.01.001
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1. (2016)
  • Author(s): Nagamori S, Wiriyasermkul P, Guarch ME, Okuyama H, Nakagomi S, Tadagaki K, Nishinaka Y, Bodoy S, Takafuji K, Okuda S, Kurokawa J, Ohgaki R, Nunes V, Palacín M, Kanai Y.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 113 Issue: 3 Pages: 775-780
  • DOI: 10.1073/pnas.1519959113
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea. (2015)
  • Author(s): Uetsuka S, Ogata G, Nagamori S, Isozumi N, Nin F, Yoshida T, Komune S, Kitahara T, Kikkawa Y, Inohara H, Kanai Y, Hibino H.
  • Journal Title: Eur J Neurosci. Volume: 42 Issue: 3 Pages: 1984-2002
  • DOI: 10.1111/ejn.12973
  • Peer Reviewed
• [Journal Article] プロテオミクスによるアミノ酸輸送と介在シグナルの全体像の解明 (2015)
  • Author(s): 永森收志
  • Journal Title: アミノ酸研究 Volume: 9 Pages: 73-77
• [Presentation] Two cystine transporters ふたつのシスチントランスポーター (2018)
  • Author(s): 永森收志
  • Organizer: 第95回日本生理学会大会 公募シンポジウム「腎尿細管トランスポーター：最近の進歩」
  • Invited
• [Presentation] Visualization and inhibition of a cancer specific amino acid transporter, LAT1低分子化合物によるがん特異的アミノ酸トランスポーターLAT1の検出と輸送阻害 (2018)
  • Author(s): 永森收志
  • Organizer: 第95回日本生理学会大会 公募シンポジウム「膜輸送研究の最前線:低分子リガンドによる制御機構の理解に向けたアプローチ」
  • Invited
• [Presentation] multi-omicsによる新規トランスポーターの生理機能解析 (2018)
  • Author(s): 永森收志
  • Organizer: 第8回生体界面研究会
• [Presentation] トランスポーターを標的とした創薬 (2018)
  • Author(s): 永森收志
  • Organizer: 岩手大学114th CRC Seminar
  • Invited
• [Presentation] 栄養食品成分の吸収・排出を担う膜輸送体の網羅的定量プロテオミクスによる変動解析Comprehensive proteomics reveals alteration of membrane transport proteins responsible for absorption and excretion of nutrients and food ingredients. (2017)
  • Author(s): 永森收志
  • Organizer: シンポジウム「栄養食品成分の吸収と排出～膜を超える仕組み」2017年度 日本農芸化学会年会
  • Place of Presentation: 京都
  • Year and Date: 2017-03-18
  • Invited
• [Presentation] 膜輸送複合体の機能的再構成人工膜 (2017)
  • Author(s): 永森收志
  • Organizer: 第6回生体界面研究会
  • Place of Presentation: 金沢
  • Year and Date: 2017-02-10
• [Presentation] Non-competitive LAT1 inhibitors suppress mTORC1 signaling similary to competitive LAT1 inhibitors (2017)
  • Author(s): Pornparn Kongpracha, Suguru Okuda, Ryuichi Ohgaki, Yoshikatsu Kanai, Shushi Nagamori
  • Organizer: 第132回 日本薬理学会近畿部会
• [Presentation] Quantitative proteomics reveal overall amino acid transport systems and the related signaling (2017)
  • Author(s): 永森收志
  • Organizer: IUNS 21st International Congress of Nutrition 2017 Scientific Symposium “Novel Functions and Uses of Amino Acids”
  • Int'l Joint Research / Invited
• [Presentation] Development of PET probes and anti-cancer drugs targeting a cancer-specific amino acid transporter, LAT1. (2017)
  • Author(s): 永森收志
  • Organizer: The 12th Asia Oceania Congress of Nuclear Medicine and Biology. Symposium “Molecular Imaging”
  • Int'l Joint Research / Invited
• [Presentation] Structure-activity relations of aromatic amino acid derivatives to interact with organic anion transporter OAT1 reveal critical moieties for renal accumulation of tumor imaging probes (2017)
  • Author(s): Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 大阪大学医学系研究フォーラム 第10回若手研究フォーラム
• [Presentation] がん細胞特異的アミノ酸トランスポーターLAT1選択的PETプローブの開発 (2017)
  • Author(s): 永森 收志、渡部 直史、金井 泰和、仲 定宏、下瀬川 恵久、畑澤 順、金井 好克
  • Organizer: 第13回 小動物インビボイメージング研究会
• [Presentation] Phosphoproteomics reveals the cellular processes affected by leucine transported through LAT1, a cancer type amino acid transporter (2017)
  • Author(s): Pornparn Kongpracha, Pattama Wiriyasermkul,, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 日本プロテオーム学会2017年大会 JHUPO 第15回大会
• [Presentation] アミノ酸トランスポーターLAT1は膜融合関連因子4F2hcの細胞膜提示による胎盤合胞体性栄養膜の形成に必須である (2017)
  • Author(s): 大垣隆一、大森崇弘、原早織、中込咲綾、金井正美、兼田（中島）加珠子、奥田傑、永森收志、金井好克
  • Organizer: 第12回 トランスポーター研究会
• [Presentation] 網羅的プロテオミクスによるアミノ酸輸送システムとその関連シグナルの全体像解明 (2017)
  • Author(s): 永森收志
  • Organizer: 日本外科代謝栄養学会第54回学術集会 アミノ酸学会ジョイントシンポジウム
  • Invited
• [Presentation] Structure-activity relationship of novel inhibitors for cancer type amino acid transporter LAT1 (2017)
  • Author(s): Pornparn Kongpracha, Pattama Wiriyasermkul,Kazuko Kaneda-Nakashima, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 第131回 日本薬理学会近畿部会
• [Presentation] A C-terminus mutation of SLC7A9 amino acid transporter retains substrate binding but diminishes the transport activity. (2017)
  • Author(s): Nagamori S, Kawamoto Y, Wiriyasermkul P, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
  • Organizer: Gordon Research Conference: Mechanisms of Membrane Transport
  • Int'l Joint Research
• [Presentation] SGLT2阻害薬カナグリフロジンによる腎刷子縁膜タンパク質の発現変動の網羅的定量プロテオミクスを用いた解析 (2017)
  • Author(s): 永森收志、齊藤隆太、五十棲規嘉、栗山千亜紀、塩谷正治、大垣隆一、奥田傑、 金井好克
  • Organizer: 第60回 日本糖尿病学会年次学術集会
• [Presentation] Heterodimeric amino acid transporters - from basic to translational research (2017)
  • Author(s): 永森收志
  • Organizer: Special Seminar at Columbia University Medical Center Department of Psychiatry/NY State Psychiatric Institute
  • Invited
• [Presentation] トランスポーターを標的とした創薬：基礎研究からのアプローチ (2017)
  • Author(s): 永森收志
  • Organizer: 富山大学薬学部「トランスポーター論」・大学院医学薬学研究部「薬物生理学研究室特別講演会」
  • Invited
• [Presentation] アミノ酸トランスポーターを標的とした創薬研究 (2016)
  • Author(s): 永森收志
  • Organizer: 第一回名古屋大学医薬系3部局交流シンポジウム ～生物学から創薬への展開～
  • Place of Presentation: 名古屋
  • Year and Date: 2016-11-07
  • Invited
• [Presentation] 腎近位尿細管に残されていた第二のシスチントランスポーターは、シスチン尿症関連タンパク質rBATの未知なる結合相手だった。 (2016)
  • Author(s): 永森收志
  • Organizer: 第89回日本生化学会大会、シンポジウム「膜輸送体学の「温故知新」～長年の謎の解明をめざして」
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-27
  • Invited
• [Presentation] Novel cystine transporter in renal proximal tubule identified as a “missing partner” of cystinuria-related membrane protein rBAT/SLC3A1 (2016)
  • Author(s): Nagamori S, Wiriyasermkul P, Espino Guarch M, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Palacin M, Kanai Y.
  • Organizer: 第25回日本尿路結石症学会
  • Place of Presentation: 千葉
  • Year and Date: 2016-07-20
• [Presentation] Significance of the comprehensive and quantitative proteomics of membrane transport proteins in drug discovery and in silico modeling. (2016)
  • Author(s): Nagamori S.
  • Organizer: International and Interdisciplinary Symposium 2016“Towards a New Era of Cardiovascular Research”
  • Place of Presentation: 東京
  • Year and Date: 2016-07-13
  • Int'l Joint Research / Invited
• [Presentation] Novel Cystine Transporter in Renal Proximal Tubule Identied as a “Missing Partner” of Cystinuria-Related Membrane Protein rBAT/SLC3A1. (2016)
  • Author(s): Nagamori S, Wiriyasermkul P, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
  • Organizer: The Kaback Symposium
  • Place of Presentation: 米国・メリーランド州ベセスダ
  • Year and Date: 2016-06-09
  • Int'l Joint Research / Invited
• [Presentation] Novel Cystine Transporter in Renal Proximal Tubule Identied as a “Missing Partner” of Cystinuria-Related Membrane Protein rBAT/SLC3A1. (2016)
  • Author(s): Nagamori S, Wiriyasermkul P, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
  • Organizer: Experimental Biology 2016
  • Place of Presentation: 米国・サンディエゴ
  • Year and Date: 2016-04-06
  • Int'l Joint Research
• [Presentation] Significance of comprehensive and quantitative proteomics of membrane transport proteins in drug discovery. (2016)
  • Author(s): Nagamori S.
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-03-11
  • Invited
• [Presentation] A renal tubular transporter mediating reabsorption of β-hydroxybutyrate: a potential target of drugs increasing urinary ketone body excretion. (2016)
  • Author(s): Nagamori S.
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-03-10
  • Invited
• [Presentation] Non-competitive inhibitors arrest the alternating-access mechanism of amino acid transporters. (2015)
  • Author(s): Nagamori S.
  • Organizer: 第38回分子生物学会年会・第88回生化学会大会合同大会（BMB2015）
  • Place of Presentation: 神戸市
  • Year and Date: 2015-12-02
  • Invited
• [Presentation] プロテオミクスによるアミノ酸輸送と介在シグナルの全体像の解明 (2015)
  • Author(s): 永森收志
  • Organizer: アミノ酸学会第9回学術大会
  • Place of Presentation: 彦根市
  • Year and Date: 2015-10-23
  • Invited
• [Presentation] 網羅的定量プロテオミクスと機能解析によるがん細胞株アミノ酸トランスポーターのプロファイリング (2015)
  • Author(s): 永森收志
  • Organizer: 平成27年度生理研研究会「生体ホメオスタシスの gatewayとしての上皮膜輸送マイクロホメオスタシス機構」
  • Place of Presentation: 岡崎
  • Year and Date: 2015-09-15
  • Invited
• [Presentation] 網羅的プロテオーム解析が捉えるアミノ酸トランスポーターによる生体システムの制御 (2015)
  • Author(s): 永森收志
  • Organizer: 平成27年（第96回）日本栄養・食糧学会関東支部大会シンポジウム
  • Place of Presentation: 新潟市
  • Year and Date: 2015-09-05
  • Invited
• [Presentation] 生体界面構成因子の定量的解析に向けた膜タンパク質定量プロテオミクス (2015)
  • Author(s): 永森收志
  • Organizer: 平成27年度生理研研究会「生体界面研究会」
  • Place of Presentation: 岡崎
  • Year and Date: 2015-07-17
  • Invited
• [Presentation] アミノ酸トランスポーターとD-アミノ酸輸送 (2015)
  • Author(s): 永森收志
  • Organizer: 第15回日本蛋白質科学会
  • Place of Presentation: 徳島市
  • Year and Date: 2015-06-24
  • Invited
• [Presentation] アミノ酸トランスポーターを標的とした創薬研究 (2015)
  • Author(s): 永森收志
  • Organizer: 第10回日本トランスポーター研究会
  • Place of Presentation: 東京都港区
  • Year and Date: 2015-06-21
  • Invited
• [Presentation] Metabolomics and proteomics of knockout mice reveal physiological function of an orphan organic anion transporter. (2015)
  • Author(s): Nagamori S.
  • Organizer: The 3rd Awaji International Workshop on “Electron Spin Science & Technology: Biological and Materials Science Oriented Applications”
  • Place of Presentation: 兵庫県淡路島
  • Year and Date: 2015-06-15
  • Int'l Joint Research / Invited