| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, to reveal the molecular mechanisms generating the complex morphology of astrocytes that play important roles in regulating neural activity, we analyzed function of Ror2 receptor tyrosine kinase in immature astrocytes in the neocortex during development and repair following brain injury. We found that Ror2 signaling promotes proliferation and motility of immature astrocytes that have a very simplified morphology. Using time-lapse imaging, we revealed that immature astrocytes stop their active movement during their maturation, and then start to elongate multiple processes from their cell body by which astrocytes acquire the complex morphology. Furthermore, our findings suggest that immature astrocytes might promote synaptogenesis via Ror2 signaling-mediated production of thrombospondin 2 and/or Hevin, thereby become morphologically mature through the interaction with newly generated synapses.
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