| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Hypoxia-resistant cancer cells are known to have highly malignant characteristics, frequently undergo metastasis, and are resistant to chemotherapy. We are long studying induction mechanisms of glycan-related genes by a transcription factor HIF, which plays a key role in acquisition of hypoxia resistance. In this project we clarified that HYAL1, which encode a degradation enzyme for hyaluronic acid, the CD44 ligand, is induced by hypoxia and is a good target for cancer therapy. We also identified GCNT2 gene to be regulated by microRNA miR-199 under hypoxia, and is also a good target for cancer therapy.
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