Comprehensive study on transcriptional induction mechanisms and pathological significance of glycan-related genes by hypoxia inducible factor, HIF
| Project/Area Number |
15K08288
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Aichi Medical University |
|---|
Principal Investigator |
Kannagi Reiji 愛知医科大学, 公私立大学の部局等, その他 (80161389)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 低酸素 / 糖鎖関連遺伝子 / CD44 / ヒアルロン酸 / micro-RNA / 転写調節 / HIF-1α / がん / microRNA / MiaTrapアッセイ / 単クローン抗体 |
|---|
| Outline of Final Research Achievements |
Hypoxia-resistant cancer cells are known to have highly malignant characteristics, frequently undergo metastasis, and are resistant to chemotherapy. We are long studying induction mechanisms of glycan-related genes by a transcription factor HIF, which plays a key role in acquisition of hypoxia resistance. In this project we clarified that HYAL1, which encode a degradation enzyme for hyaluronic acid, the CD44 ligand, is induced by hypoxia and is a good target for cancer therapy. We also identified GCNT2 gene to be regulated by microRNA miR-199 under hypoxia, and is also a good target for cancer therapy.
|
Report
(4 results)
Research Products
(15 results)
-
[Journal Article] Concerted mass spectrometry-based glycomic approach for precision mapping of sulfo sialylated N-glycans on human peripheral blood mononuclear cells and lymphocytes2017
Author(s)
Chen, J. Y., Huang, H. H., Yu, S. Y., Wu, S. J., Kannagi, R., and Khoo, K. H.
-
Journal Title
Glycobiology
Volume: 28
Issue: 1
Pages: 9-20
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
[Journal Article] Downregulation of miR-199a/b-5p is associated with GCNT2 induction upon epithelial-mesenchymal transition in colon cancer2017
Author(s)
Chao, C. C., Wu, P. H., Huang, H. C., Chung, H. Y., Chou, Y. C., Cai, B. H., and Kannagi, R.
-
Journal Title
FEBS Lett.,
Volume: 591
Issue: 13
Pages: 1902-1917
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
