| Project/Area Number |
15K08290
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kurume University |
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Principal Investigator |
Yamamoto Ken 久留米大学, 医学部, 教授 (60274528)
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| Co-Investigator(Kenkyū-buntansha) |
原田 二朗 久留米大学, 医学部, 講師 (10373094)
大中 佳三 九州大学, 医学研究院, 講師 (30325518)
塚口 舞 (古澤舞) 久留米大学, 医学部, 助教 (40624094)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | DNAメチレーション / 加齢 / ELOVL2 / KLF14 / DNA methylation / aging / エピゲノム / ＤＮＡメチル化 / DNAメチル化 |
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| Outline of Final Research Achievements |
DNA methylation sites whose methylation level changes with aging were identified on 7 gene regions. Among them, ELOVL2 involved in blood levels of EPA and DHA, and KLF14 involved in type 2 diabetes were included. The age-responsive epigenome region of the ELOVL2 was observed in mice, and it is remarkable in the lung, spleen and large intestine. This suggested that it is fundamental biological phenomenon conserved beyond species. Epigenomic changes affecting onset of myocardial infarction were identified. We also elucidated the characteristics of the epigenome in LCL derived from human. In addition, the increase in DNA methylation of KLF14 with aging was reproduced in mouse adipocytes and showed that it is promoted by a high fat diet.
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