Roles for monoacylglycerol lipase in lipid homoestasis
Project/Area Number |
15K08296
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
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Research Institution | The University of Tokyo |
Principal Investigator |
Kita Yoshihiro 東京大学, 大学院医学系研究科(医学部), 准教授 (20401028)
|
Co-Investigator(Renkei-kenkyūsha) |
TOKUOKA Suzumi. M. 東京大学, 大学院医学系研究科, 特任助教 (60511376)
HAMANO Fumie 国立研究開発法人国立国際医療研究センター, 上級研究員 (80548511)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 脂質ホメオスタシス / エネルギー代謝 / 肥満 / モノアシルグリセロールリパーゼ |
Outline of Final Research Achievements |
We evaluated the role(s) for monoacylglycerol lipase (MGL) in energy homeostasis, using MGL- deficient mice and CB1-MGL double-deficient mice. MGL-deficient mice showed delayed intestinal lipid absorption, which was completely CB1-independent, as CB1-MGL deficient mice but not CB1-single deficient mice showed a similar phenotype. Both MGL-deficient mice and CB1-MGL double-deficient mice, but not CB1-single deficient mice showed strong suppression in feeding behavior after lipid gavage. This phenotype was partially rescued by vagotomy, suggesting MGL's role in satiety regulation through gut-brain axis.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Relief from neuropathic pain by blocking of platelet-activating factor-pain loop.2017
Author(s)
Shindou, H., Shiraishi, S., Tokuoka, S. M., Takahashi, Y., Harayama, T., Abe, T., Bando, K., Miyano, K., Kita, Y., Uezono, Y., Shimizu, T.
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Journal Title
FASEB J
Volume: -
Issue: 7
Pages: 2973-2980
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Imaging of Intracellular Fatty Acids by Scanning X-ray Fluorescence Microscopy.2016
Author(s)
Shimura, M., Shindou, H, Szyrwiel, L., Tokuoka, M.S., Hamano, F., Matsuyama, S., Okamoto, M., Matsunaga, A., Kita, Y., Ishizaka, Y., Yamauchi, K., Komura, Y., Lobinski, R., Shimizu, I., Shimizu, T. *, equal contribution
#, equal corresponding author
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Journal Title
FASEB J.
Volume: 30
Issue: 12
Pages: 4149-4158
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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