| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Cell movement directed by a gradient of a diffusible chemoattractant is known as chemotaxis, which plays a vital role in immune responses. Neutrophilic leukocytes, crucial for host defense, move toward the source of chemoattractants, which are derived from invading microbes and/or produced by infected hosts, thereby arriving correctly at sites of infection for pathogen killing. Although neutrophil chemotaxis requires not only increased motility but also directional movement, molecular mechanisms for directionality control have remained largely unknown. We have previously reported that Inscuteable protein regulates directionality of chemotaxing neutrophils by tethering chemoattractant-elicited trimeric-Gi-protein signaling to an evolutionarily-conserved Par-polarity-protein complex. Here, we have identified downstream regulators of the polarity complex for directionality control during neutrophil chemotaxis.
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