Pathological analysis of Alzheimer`s disease through multi-layered omics study of blood exosomes derived from brain
| Project/Area Number |
15K08326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
TAKIKAWA Osamu 国立研究開発法人国立長寿医療研究センター, その他部局等, その他(移行) (70163342)
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| Co-Investigator(Kenkyū-buntansha) |
奥野 海良人 国立研究開発法人国立長寿医療研究センター, その他部局等, その他 (50623980)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 認知症 / アルツハイマー病 / エクソソーム / リキッドバイオプシー / 多層的オミックス解析 / 神経細胞由来エクソソーム / アストロサイト由来エクソソーム / 脳リキッドバイオプシー / オミックス解析 / 軽度認知症障害 / 代謝異常学 / 疾患エクソソーム |
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| Outline of Final Research Achievements |
Alzheimer's disease (AD) accounts for the majority of dementia. Therapeutic drug development for AD has long been conducted, targeting amyloid β peptide (Aβ) based on amyloid hypothesis but it has not succeeded yet.
In this study, to identify novel molecular targets for drug development for AD, non-biased multilayered comprehensive analysis of proteins, metabolites, and miRNAs of exosomes in plasma derived from brain cells (neurons and astrocytes) of mild cognitive impairment (MCI) and AD was planned and to this end, we first tried to establish the reliable isolation method of neuron-derived exosomes (NDE) and astrocyte-derived exosomes (ADE) from human plasma.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Metabolome analysis reveals the association between the kynurenine pathway and human herpesvirus 6 encephalopathy in immunocompetent children2017
Author(s)
Torii, Y. Kawano, Y. Sato, H. Fujimori, T. Sasaki, K. Kawada, J. Takikawa, O. Lim, C. K. Guillemin, G. J. Ohashi, Y. Ito, Y.
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Journal Title
Metabolomics
Volume: 13
Issue: 11
Pages: 126-126
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] New Inhibitors of Indoleamine 2,3-Dioxygenase 1: Molecular Modeling Studies, Synthesis, and Biological Evaluation.2016
Author(s)
Coluccia A, Passacantilli S, Famiglini V, Sabatino M, Patsilinakos A, Ragno R, Mazzoccoli C, Sisinni L, Okuno A, Takikawa O, Silvestri R, La Regina G.
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Journal Title
J Med Chem.
Volume: 59
Pages: 9760-9773
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B.2016
Author(s)
Yoshio S, Sugiyama M, Shoji H, Mano Y, Mita E, Okamoto T, Matsuura Y, Okuno A, Takikawa O, Mizokami M, Kanto T.
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Journal Title
Hepatology
Volume: 63
Issue: 1
Pages: 83-94
DOI
Related Report
Peer Reviewed
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