Regulation and diversity of ligands for NK receptors in immunity
| Project/Area Number |
15K08328
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Human genetics
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
NARUSE Taeko 東京医科歯科大学, 難治疾患研究所, プロジェクト助教 (80422476)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
木村 彰方 東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | NKレセプターリガンド / ULBP / MIC / ゲノム多様性 / 遺伝子発現 / 遺伝子 / 遺伝学 / ゲノム / 人類学 / 免疫学 / ＮＫレセプターリガンド |
|---|
| Outline of Final Research Achievements |
Natural-killer group 2 member D (NKG2D), a C-type lectin molecule, is an activating receptor. In human, UL-16 binding protein (ULBP) / retinoic acid early transcript 1 (REAT1) family and MHC class I chain-related gene, MICA and MICB, are known to encode ligands for NKG2D. A polymorphism causing a valine to methionine exchange at position129 affects binding to NKG2D, cytotoxicity, interferon-γ release by NK cells and activation of CD8+ T cells. We investigated whether the polymorphism affects susceptibility to inflammatory disease such as Ulcerative colitis (UC), Crohn's disease (CD) and Takayasu disease. We found significantly higher frequencies of MIC129V/V in patients with UC or Takayasu disease whereas no association was found for CD.
|
Report
(4 results)
Research Products
(14 results)
-
-
-
-
[Journal Article] Diversity of MHC class I alleles in Spheniscus humboldti.2016
Author(s)
Kikkawa, E., Tanaka, M., Naruse, T. K., Tsuda, T. T., Tsuda, M., Murata, K. and Kimura, A.
-
Journal Title
Immunogenetics
Volume: 69
Issue: 2
Pages: 113-124
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Presentation] IkBL regulates susceptibility to HIV-1 infection.2016
Author(s)
Kimura A, Naruse T K, Sakurai D,Jianbo An, OHtani H, Terunuma H, Nakayama E E, Shioda T, Gaurav Sharma, Mehra N K, Kaur G,
Organizer
The 13th International Congress of Human genetics
Place of Presentation
京都国際会議場（京都府京都市）
Year and Date
2016-04-03
Related Report
Int'l Joint Research
-
-
