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Regulation and diversity of ligands for NK receptors in immunity

Research Project

Project/Area Number 15K08328
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human genetics
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NARUSE Taeko  東京医科歯科大学, 難治疾患研究所, プロジェクト助教 (80422476)

Co-Investigator(Kenkyū-buntansha) 木村 彰方  東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsNKレセプターリガンド / ULBP / MIC / ゲノム多様性 / 遺伝子発現 / 遺伝子 / 遺伝学 / ゲノム / 人類学 / 免疫学 / NKレセプターリガンド
Outline of Final Research Achievements

Natural-killer group 2 member D (NKG2D), a C-type lectin molecule, is an activating receptor. In human, UL-16 binding protein (ULBP) / retinoic acid early transcript 1 (REAT1) family and MHC class I chain-related gene, MICA and MICB, are known to encode ligands for NKG2D. A polymorphism causing a valine to methionine exchange at position129 affects binding to NKG2D, cytotoxicity, interferon-γ release by NK cells and activation of CD8+ T cells. We investigated whether the polymorphism affects susceptibility to inflammatory disease such as Ulcerative colitis (UC), Crohn's disease (CD) and Takayasu disease. We found significantly higher frequencies of MIC129V/V in patients with UC or Takayasu disease whereas no association was found for CD.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] 全インド医科学研究所(インド)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] 全インド医科学研究所(インド)

    • Related Report
      2015 Research-status Report
  • [Journal Article] MKL1 expressed in macrophages contributes to the development of murine colitis.2017

    • Author(s)
      Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 13650-13650

    • DOI

      10.1038/s41598-017-13629-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diversity of MHC class I alleles in Spheniscus humboldti.2016

    • Author(s)
      Kikkawa, E., Tanaka, M., Naruse, T. K., Tsuda, T. T., Tsuda, M., Murata, K. and Kimura, A.
    • Journal Title

      Immunogenetics

      Volume: 69 Issue: 2 Pages: 113-124

    • DOI

      10.1007/s00251-016-0951-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] MICA-129多型は高安病の感受性因子である2017

    • Author(s)
      成瀬妙子、木村彰方
    • Organizer
      第26回日本組織適合性学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 次世代シーケンサー(NGS)を用いたアカゲザルMHCクラスI遺伝子タイピン群タイピング法の開発2017

    • Author(s)
      谷本幸介、成瀬妙子、俣野哲朗、木村彰方
    • Organizer
      第26回日本組織適合性学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 炎症性腸疾患の病態形成におけるMKL1の役割2017

    • Author(s)
      安健博、永石宇司、渡部太郎、成瀬妙子、渡辺守、木村彰方
    • Organizer
      第26回日本組織適合性学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フンボルトペンギンMHCクラスIIβ遺伝子のゲノム構造2017

    • Author(s)
      吉川枝里、田中正史、津田とみ、村田浩一、成瀬妙子、木村彰方
    • Organizer
      第26回日本組織適合性学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] MICA-129多型は炎症性自己免疫疾患の感受性因子である2017

    • Author(s)
      成瀬妙子、木村彰方
    • Organizer
      日本人類遺伝学会 第62回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] MICA-129多型は炎症性自己免疫疾患の感受性因子か?2016

    • Author(s)
      成瀬 妙子、木村 彰方
    • Organizer
      第25回日本組織適合性学会大会
    • Place of Presentation
      北海道大学学術交流会館(北海道札幌市)
    • Year and Date
      2016-10-22
    • Related Report
      2016 Research-status Report
  • [Presentation] APOBECH3H polymorphisms are associated with susceptibility to HIV-1 Infection and development of AIDS in Asian populations.2016

    • Author(s)
      Naruse T K, Sakurai D,OHtani H, Terunuma H, Iwatani Y, Sugiura W, Gaurav Sharma, Mehra N K, Kaur G, Kimura A
    • Organizer
      The 13th International Congress of Human genetics
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2016-04-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] IkBL regulates susceptibility to HIV-1 infection.2016

    • Author(s)
      Kimura A, Naruse T K, Sakurai D,Jianbo An, OHtani H, Terunuma H, Nakayama E E, Shioda T, Gaurav Sharma, Mehra N K, Kaur G,
    • Organizer
      The 13th International Congress of Human genetics
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2016-04-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] IkBLによるHIV-1感染感受性の制御2015

    • Author(s)
      2.成瀬妙子、櫻井大祐、安 健博、中山英美、塩田達雄、Gaurav Sharma、Narinder Mehra、Gurvinder Kaur、木村彰方
    • Organizer
      日本人類遺伝学会第60回大会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Research-status Report
  • [Presentation] IkBLはHIV-1感受性を制御する.2015

    • Author(s)
      1.成瀬妙子、櫻井大祐、安 健博、中山英美、塩田達雄、Gaurav Sharma、Narinder Mehra、Gurvinder Kaur、木村彰方
    • Organizer
      第 24回日本組織適合性学会大会
    • Place of Presentation
      ホテルレイクビュー水戸(茨城県水戸市)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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