| Project/Area Number |
15K08328
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NARUSE Taeko 東京医科歯科大学, 難治疾患研究所, プロジェクト助教 (80422476)
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| Co-Investigator(Kenkyū-buntansha) |
木村 彰方 東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | NKレセプターリガンド / ULBP / MIC / ゲノム多様性 / 遺伝子発現 / 遺伝子 / 遺伝学 / ゲノム / 人類学 / 免疫学 / ＮＫレセプターリガンド |
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| Outline of Final Research Achievements |
Natural-killer group 2 member D (NKG2D), a C-type lectin molecule, is an activating receptor. In human, UL-16 binding protein (ULBP) / retinoic acid early transcript 1 (REAT1) family and MHC class I chain-related gene, MICA and MICB, are known to encode ligands for NKG2D. A polymorphism causing a valine to methionine exchange at position129 affects binding to NKG2D, cytotoxicity, interferon-γ release by NK cells and activation of CD8+ T cells. We investigated whether the polymorphism affects susceptibility to inflammatory disease such as Ulcerative colitis (UC), Crohn's disease (CD) and Takayasu disease. We found significantly higher frequencies of MIC129V/V in patients with UC or Takayasu disease whereas no association was found for CD.
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