| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We analyzed the expression of phenotypic markers characterizing primitive cells and its correlation with clinicopathologic and molecular characteristics in a series of gastric cancer (n = 386). On the basis of the expression profiles, 20% of tumors were identified as gastric cancer with primitive phenotype, and were characterized by intestinal type histology including AFP-producing adenocarcioma, frequent vascular invasion and nodal metastasis. This subgroup was associated with patients’ poor prognosis and was an independent risk factor for disease-free survival. In terms of molecular alteration, they showed frequent TP53 alterations and little association with Epstein-Barr virus or microsatellite instability, and were mostly classified as “chromosomal instability” subtype in the Cancer Genome Atlas’ molecular classification. We also clarified clinicopathological characteristics of diffuse type gastric cancer with RHOA mutation.
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