| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
This study addressed to clarify a pathogenesis of primary biliary cholangitis (PBC), putting focus on the association of dysregulated autophagy with abnormal expression of mitochondrial antigens. This study also addressed to develop a useful diagnostic marker for PBC. This study revealed that immunohistochemical detection of dysregulated autophagy and abnormal expression of mitochondrial antigens is a useful marker for a diagnosis of recurrent PBC after liver transplantation and cryptogenic cirrhosis. Furthermore, this study disclosed that anion exchanger 2 (AE2), which plays a role in the protection of biliary mucosa by maintaining biliary bicarbonate umbrella, showed decreased expression in the bile duct lesion in PBC. Cell culture study demonstrated that the decreased expression of AE2 was associated with dysregulated autophagy, abnormal expression of mitochondrial antigens and cellular senescence in biliary epithelial cells in PBC.
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