| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Mononuclear cell infiltrates in ulcerative colitis (UC) mucosa are considered to be recruited via high endothelial venule (HEV)-like vessels displaying mucosal addressin cell adhesion molecules 1 (MAdCAM-1), the ligand for integrin, and/or peripheral lymph node addressin (PNAd), an L-selectin ligand. 6-O-sulfation of N-acetylglucosamine in PNAd is catalyzed by N-acetylglucosamine-6-O-sulfotransferase 1 (GlcNAc6ST-1) and GlcNAc6ST-2. To determine the role of 6-O-sulfation on HEV-like vessels in UC, we employed a colitis model using mice deficient in both sulfotransferases (DKO mice). We found that more inflammatory cells were infiltrated in DKO mouse colitis, and the number of MAdCAM-1-positive vessels was increased in DKO mouse colitis. These findings suggest that MAdCAM-1 compensates PNAd function and contributes to the pathogenesis of UC in DKO mice.
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