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Molecular and immunohistochemical analysis of BART expression controlling the inhibition to pancreatic cancer invasion and metastasis

Research Project

Project/Area Number 15K08346
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionKochi University

Principal Investigator

FURIHATA Mutsuo  高知大学, 教育研究部医療学系連携医学部門, 教授 (10209158)

Co-Investigator(Kenkyū-buntansha) 谷内 恵介  高知大学, 医学部附属病院, 特任准教授 (50626869)
岩崎 信二  高知大学, 教育研究部医療学系臨床医学部門, 准教授 (10232654)
Project Period (FY) 2015-10-21 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords膵癌 / 浸潤転移 / RNA結合蛋白 / RNA結合蛋白RNA / 免疫組織化学 / RNA結合蛋白 RNA / RNA結合蛋白 RNA
Outline of Final Research Achievements

We previously reported that mRNA-binding protein-bound transcripts accumulate in membrane protrusions of pancreatic ductal adenocarcinoma (PDAC) cells, and the formation of additional membrane protrusions increased the invasive and metastatic properties of the PDAC cells. In the course of this investigation, we picked up the three mRNA-binding proteins; Var3, PODXL and CCDC88, and demonstrated that these candidate markers were accumulated in cell protrusions, contributed to the formation of membrane protrusions, and increased the migration and invasiveness of PDAC cells. In contrast, knockdown of each of them inhibited the motility and invasiveness of PDAC. Immunohistochemistry leveled that high expression of these proteins was an independent predictor of worse overall survival of pancreatic cancer patients. Our studies suggest that they can be a useful marker for predicting the outcome of patients with PDAC and thereby increased the motility and invasiveness of PDAC.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (17 results)

All 2017 2016 2015

All Journal Article (12 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Open Access: 12 results,  Acknowledgement Compliant: 5 results) Presentation (5 results)

  • [Journal Article] The fifth epidermal growth factor-like region of thrombomodulin exerts cytoprotective function and prevents SOS in a murine model2017

    • Author(s)
      Takayuki Ikezoe, Jing Yang, Chie Nishioka, Bin Pan, Kailin Xu, Mutsuo Furihata, Keigo Nakamura, Hiroya Yurimoto, Yasuyoshi Sakai, Goichi Honda, and Akihito Yokoyama
    • Journal Title

      Bone Marrow Transplant.

      Volume: 52 Issue: 1 Pages: 73-79

    • DOI

      10.1038/bmt.2016.195

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression of Cadherin-17 Promotes Metastasis in a Highly Bone Marrow Metastatic Murine Breast Cancer Model.2017

    • Author(s)
      Okada T, Kurabayashi A, Akimitsu N, Furihata M
    • Journal Title

      Biomed Res Int.

      Volume: - Pages: 1-10

    • DOI

      10.1155/2017/8494286

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SHISA2 enhances the aggressive phenotype in prostate cancer through the regulation of WNT5A expression.2017

    • Author(s)
      Tamura K, Furihata M, Satake H, Hashida H, Kawada C, Osakabe H, Fukuhara H, Kumagai N, Iiyama T, Shuin T, Inoue K
    • Journal Title

      Oncol Lett.

      Volume: 14(6) Pages: 6650-6658

    • DOI

      10.3892/ol.2017.7099

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vav3 is linked to poor prognosis of pancreatic cancers and promotes the motility and invasiveness of pancreatic cancer cells.2016

    • Author(s)
      Tsuboi M, Taniuchi K, Furihata M, Naganuma S, Kimura M, Watanabe R, Shimizu T, Saito M, Dabanaka K, Hanazaki K, Saibara T.
    • Journal Title

      Pancreatology.

      Volume: 16 Issue: 5 Pages: 905-16

    • DOI

      10.1016/j.pan.2016.07.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Podocalyxin-like protein, linked to poor prognosis of pancreatic cancers, promotes cell invasion by binding to gelsolin.2016

    • Author(s)
      Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Hanazaki K, Saibara T.
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 10 Pages: 1430-1442

    • DOI

      10.1111/cas.13018

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells.2016

    • Author(s)
      Tanouchi A, Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Kimura M, Watanabe R, Kohsaki T, Shimizu T, Saito M, Hanazaki K, Saibara T.
    • Journal Title

      J Exp Clin Cancer Res.

      Volume: 35 Issue: 1 Pages: 190-190

    • DOI

      10.1186/s13046-016-0466-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prdx1 promotes pancreatic cancer cell invasion by modulating p38 MAPK activity.2015

    • Author(s)
      Taniuchi K, Furihata M, Hanazaki K, Iwasaki S, Tanaka K, Shimizu T, Saito M, Saibara T
    • Journal Title

      Pancreas

      Volume: 44 Issue: 2 Pages: 331-340

    • DOI

      10.1097/mpa.0000000000000270

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Observation of tissues in open aqueous solution by atmospheric scanning electron microscopy: applicability to intraoperative cancer diagnosis2015

    • Author(s)
      N.Memtily, T.Okada, T.Ebihara, M.Sato, A.Kurabayashi, M.Furihata, M.Suga, H.Nishiyama, K.Mio, C.Sato
    • Journal Title

      Int J Oncol

      Volume: 46 Issue: 5 Pages: 1872-1882

    • DOI

      10.3892/ijo.2015.2905

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Combination with third-generation bisphosphonate (YM529) and interferon-alpha can inhibit the progression of established bone renal cell carcinoma.2015

    • Author(s)
      Kurabayashi A, Inoue K, Fukuhara H, Karashima T, Fukata S, Kawada C, Shuin T, Furihata M
    • Journal Title

      Cancer Sci.

      Volume: 106(8) Issue: 8 Pages: 1092-1099

    • DOI

      10.1111/cas.12711

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Performance of 5-aminolevulinic-acid-based photodynamic diagnosis for radical prostatectomy.2015

    • Author(s)
      Fukuhara H, Inoue K, Kurabayashi A, Furihata M, Shuin T
    • Journal Title

      BMC Urol.

      Volume: 15 Issue: 1 Pages: 78-78

    • DOI

      10.1186/s12894-015-0073-y

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Silencing of ATPase Inhibitory Factor 1 Inhibits Cell Growth via Cell Cycle Arrest in Bladder Cancer.2015

    • Author(s)
      Wei S, Fukuhara H, Kawada C, Kurabayashi A, Furihata M, Ogura S, Inoue K, Shuin T
    • Journal Title

      Pathobiology.

      Volume: 82(5) Issue: 5 Pages: 224-232

    • DOI

      10.1159/000439027

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intramucosal Signet Ring Cell Gastric Cancer Diagnosed 15 Months after the Initial Endoscopic Examination.2015

    • Author(s)
      Taniuchi K, Ookawauchi K, Kumon K, Sumiyoshi T, Iwata J, Furihata M, Nakamura T, Uchiumi J
    • Journal Title

      Case Rep Med.

      Volume: 2015 Pages: 479625-479625

    • DOI

      10.1155/2015/479625

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Hindlimb IR effects on glucose metabolism in the hepatocytes via a brain-liver neurocircuit.2017

    • Author(s)
      倉林 睦,田中千遥,松本和花,長沼誠二,降幡睦夫
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 後肢虚血―再灌流刺激の肝糖代謝への影響と中枢神経を介したそのメカニズム2017

    • Author(s)
      倉林 睦, 田中千遥, 松本和花, 長沼誠二, 降幡睦夫,柿沼由彦
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 食道扁平上皮癌浸潤部におけるNotch1 の核内発現は生命予後不良の予測因子となりうる2017

    • Author(s)
      長沼誠二,喜多芳明,中川 裕,北川博之, 倉林 睦, 田中千遥, 松本和花,花﨑和弘,夏越祥次, 降幡睦夫
    • Organizer
      第35回日本ヒト細胞学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生体肝移植後に発症した大脳原発リンパ腫の一例2017

    • Author(s)
      田中千遥,倉林 睦,松本和花,長沼誠二,弘井 誠,村上一郎,降幡睦夫
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 著明な静脈の変化を伴った静脈硬化性大腸炎の一例2017

    • Author(s)
      池田一岐,長沼誠二,倉林 睦,村上一郎,降幡睦夫
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report

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Published: 2015-10-21   Modified: 2019-03-29  

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