| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality worldwide. An excess of iron in liver tissue causes oxidative stress, leading to hepatocellular carcinogenesis. Iron metabolism, which is regulated by a complex mechanism, is important for cancer cell survival. The aim of this study is to clarify the role of iron regulatory protein in the progression of HCC and in patient outcome. High expression of TFR1 in HCC was associated with liver cirrhosis (p<0.0001), higher alpha-fetoprotein (AFP) (p<0.0001), smaller tumor size (p=0.0022), poor histological differentiation (p<0.0001) and morphological features (p<0.0001). Multivariate analysis for both overall survival and recurrence-free survival indicated that high TFR1 expression was a significant prognostic factor for poor outcome. TFR1 overexpression suggests a higher risk of recurrence and death in HCC patients following liver resection.
|
