Analysis of antioxidant-related AMPK pathway in the onset and progression of non-alcoholic steatohepatitis (NASH).
| Project/Area Number |
15K08353
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
OIKAWA KANTA 岩手医科大学, 医学部, 研究員 (00405804)
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| Co-Investigator(Kenkyū-buntansha) |
増田 友之 岩手医科大学, 医学部, 教授 (10199698)
前沢 千早 岩手医科大学, 医学部, 教授 (10326647)
及川 浩樹 岩手医科大学, 医学部, 講師 (50285582)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | NASH / AMPK / SOD2 / Catalase / 8OHdG / SOD / catalase / FOXO3a / CaMKK2 / ROS / FOX3a / LKB1 |
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| Outline of Final Research Achievements |
Thirty seven cases of NASH and forty cases of NAFL were immunohistochemically examined. 8OHdG and 4-HNE which was oxidation stress-related were over expression in NASH. SOD2 and Catalase which was antioxidation-related on NASH were not recognize significant difference compared with NAFL. The protein and mRNA with NASH model in a cultured cell showed over expression on LKB1, AMPK, FOXO3a. However SOD2 and Catalase were not recognized significant difference. Knockdown of the AMPK induced the inhibition of FOXO3a, SOD2 and Catalase.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Camosic acid, an inhibitor of NAD(P)H quinone oxidoreductase 1, enhances the cytotoxicity of β-lapachone in melanoma cell lines.2018
Author(s)
Arakawa N, Okubo A, Yasuhira S, Takahashi K, Amano H, Akasaka T, Masuda T, Shibazaki M, Maesawa C.
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Journal Title
Oncol Lett
Volume: 15
Pages: 2393-2400
DOI
Related Report
Peer Reviewed / Open Access
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