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Analysis of antioxidant-related AMPK pathway in the onset and progression of non-alcoholic steatohepatitis (NASH).

Research Project

Project/Area Number 15K08353
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionIwate Medical University

Principal Investigator

OIKAWA KANTA  岩手医科大学, 医学部, 研究員 (00405804)

Co-Investigator(Kenkyū-buntansha) 増田 友之  岩手医科大学, 医学部, 教授 (10199698)
前沢 千早  岩手医科大学, 医学部, 教授 (10326647)
及川 浩樹  岩手医科大学, 医学部, 講師 (50285582)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsNASH / AMPK / SOD2 / Catalase / 8OHdG / SOD / catalase / FOXO3a / CaMKK2 / ROS / FOX3a / LKB1
Outline of Final Research Achievements

Thirty seven cases of NASH and forty cases of NAFL were immunohistochemically examined. 8OHdG and 4-HNE which was oxidation stress-related were over expression in NASH. SOD2 and Catalase which was antioxidation-related on NASH were not recognize significant difference compared with NAFL. The protein and mRNA with NASH model in a cultured cell showed over expression on LKB1, AMPK, FOXO3a. However SOD2 and Catalase were not recognized significant difference. Knockdown of the AMPK induced the inhibition of FOXO3a, SOD2 and Catalase.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (6 results)

  • [Journal Article] Camosic acid, an inhibitor of NAD(P)H quinone oxidoreductase 1, enhances the cytotoxicity of β-lapachone in melanoma cell lines.2018

    • Author(s)
      Arakawa N, Okubo A, Yasuhira S, Takahashi K, Amano H, Akasaka T, Masuda T, Shibazaki M, Maesawa C.
    • Journal Title

      Oncol Lett

      Volume: 15 Pages: 2393-2400

    • DOI

      10.3892/ol.2017.7618

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyaluronic acid enhances cell migration and invasion via the YAP1/TAZ-RHAMM axis in malignant pleural mesothelioma2017

    • Author(s)
      Shigeeda W, Shibazaki M, Yasuhira S, Masuda T, Tanita T, Kaneko Y, Sato T, Sekido Y, Maesawa C.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 55 Pages: 93729-93740

    • DOI

      10.18632/oncotarget.20750

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Predicted Energy Expenditure in Japanese Patients with Non-Alcoholic Fatty Liver Disease to Establish a Suitable Nutrition Intervention2016

    • Author(s)
      Endo K, Kakisaka K, Oikawa K, Endo R, Takikawa Y.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 62 Issue: 2 Pages: 108-115

    • DOI

      10.3177/jnsv.62.108

    • NAID

      130005154257

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] NAD(P)H dehydrogenase, quinone 1 (NQO1), protects melanin-producing cells from cytotoxicity of rhododendrol.2016

    • Author(s)
      Okubo A, Yasuhira S, Shibazaki M, Takahashi K, Akasaka T, Masuda T, Maesawa C.
    • Journal Title

      Pigment Cell Melanoma Res.

      Volume: 29 Issue: 3 Pages: 309-16

    • DOI

      10.1111/pcmr.12461

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.2016

    • Author(s)
      Kasai S, Arakawa N, Okubo A, Shigeeda W, Yasuhira S, Masuda T, Akasaka T, Shibazaki M, Maesawa C.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 4 Pages: e0153181-e0153181

    • DOI

      10.1371/journal.pone.0153181

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tatemichi Y, Shibazaki M, Yasuhira S, Kasai S, Tada H, Oikawa H, Suzuki Y, Takikawa Y, Masuda T, Maesawa C.2015

    • Author(s)
      Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification.
    • Journal Title

      Cancer Sci.

      Volume: 106 Issue: 7 Pages: 848-56

    • DOI

      10.1111/cas.12680

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bimodal peaks of liver stiffness in a case of drug-induced liver injury.2015

    • Author(s)
      Kakisaka K, Kooka Y, Oikawa T, Suzuki A, Oikawa K, Kuroda H, Kasai K,
    • Journal Title

      Hepatol Res.

      Volume: 45 Issue: 3 Pages: 343-8

    • DOI

      10.1111/hepr.12341

    • NAID

      120005867727

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Helicobacter pylori感染診断における鏡検法の評価2017

    • Author(s)
      及川寛太 及川浩樹 及川純子 及川慶一 増田友之
    • Organizer
      第106回 日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京 新宿)
    • Year and Date
      2017-04-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 肝細胞癌浸潤能に及ぼすafadinの発現変化の検討2017

    • Author(s)
      及川浩樹 及川寛太 増田友之
    • Organizer
      第106回 日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京 新宿)
    • Year and Date
      2017-04-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 肝細胞癌浸潤能に及ぼすafadinの発現変化の検討2017

    • Author(s)
      及川 浩樹、及川 寛太、水谷 久太、増田 友之
    • Organizer
      第106回日本病理学学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Helicobactor pylori感染診断における鏡検法の評価2017

    • Author(s)
      及川 寛太、及川 浩樹、及川 純子、及川 慶一、増田 友之
    • Organizer
      第106回日本病理学学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患の病理組織学的な酸化ストレスマーカーの意義2015

    • Author(s)
      及川寛太, 及川純子, 及川慶一, 水谷久太, 阿保亜紀子, 及川浩樹, 前沢千早, 佐藤孝, 増田友之
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
  • [Presentation] RhoGDI2の発現変化による大腸癌進展の検討2015

    • Author(s)
      及川浩樹、及川寛太、若杉優樹、根岸駿、水谷久太、増田友之
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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