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A cell lineage of breast cancer consisting of different histologic types by mutation analysis of mtDNA D-loop region

Research Project

Project/Area Number 15K08357
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionNihon University

Principal Investigator

MASUDA Shinobu  日本大学, 医学部, 教授 (20276794)

Co-Investigator(Renkei-kenkyūsha) ESUMI Mariko  日本大学, 医学部, 客員教授 (10147019)
TOU Shoen  日本大学, 医学部, 准教授 (20326036)
AMANO Sadao  日本大学, 医学部, 客員教授 (80159459)
SAKURAI Kenichi  日本大学, 医学部, 准教授 (20366602)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords乳癌 / 細胞系譜 / 乳管癌 / 小葉癌 / ミトコンドリアDNA / 組織型 / 混合型 / 遺伝子変異 / mitochondrial DNA / Mitochondrial DNA
Outline of Final Research Achievements

The aim of study was to reveal cell lineage of cancer cells behind the characteristics of pathological morphology. Combined lobular and ductal carcinomas were submitted to this study. Genetic alteration of D-loop region of mitochondrial DNA and 409 nuclear genes were analyzed. Closely located cancer cells have a possibility to be originated from an identical cancer cell even though cancer cells were classified into different histological types. It is also suggested that cancer cells far from each other in different segments might be different cell origin, even though they were classified into the same histological type. This study enables us to look into the cell lineage of cancer cells in relation to histological type.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (34 results)

All 2018 2017 2016 2015

All Journal Article (22 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 22 results,  Open Access: 16 results,  Acknowledgement Compliant: 6 results) Presentation (12 results) (of which Invited: 4 results)

  • [Journal Article] Inter-observer agreement among pathologists in grading the pathological response to neoadjuvant chemotherapy in breast cancer2018

    • Author(s)
      Yamaguchi T, Mukai H, Akiyama F, Arihiro K, Masuda S, Kurosumi M, Kodama Y, Horii R, Tsuda H
    • Journal Title

      Breast Cancer

      Volume: 25 Issue: 1 Pages: 118-125

    • DOI

      10.1007/s12282-017-0799-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumour-infiltrating lymphocytes (TILs)-related genomic signature predicts chemotherapy response in breast cancer2018

    • Author(s)
      Kochi M, Iwamoto T, Niikura N, Bianchini G, Masuda S, Mizoo T, Nogami T, Shien T, Motoki T, Taira N, Tokuda Y, Doihara H, Matsuoka J, Fujiwara T
    • Journal Title

      Breast Cancer Research and Treatment

      Volume: 167 Issue: 1 Pages: 39-47

    • DOI

      10.1007/s10549-017-4502-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation between the Ki-67 proliferation index and response to radiation therapy in small cell lung cancer2017

    • Author(s)
      Ishibashi N, Maebayashi T, Aizawa T, Sakaguchi M, Nishimaki H, Masuda S
    • Journal Title

      Radiation Oncology

      Volume: 12 Issue: 1 Pages: 16-16

    • DOI

      10.1186/s13014-016-0744-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of cell death in pancreatic ductal adenocarcinoma by indirubin 3'-oxime and 5-methoxyindirubin 3'-oxime in vitro and in vivo.2017

    • Author(s)
      Sano M, Ichimaru Y, Kurita M, Hayashi E, Homma T, Saito H, Masuda S, Nemoto N, Hemmi A, Suzuki T, Miyairi S, Hao H
    • Journal Title

      Cancer Letters

      Volume: 397 Pages: 72-82

    • DOI

      10.1016/j.canlet.2017.03.031

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An autopsy case of hyperthyroid cardiomyopathy manifesting lethal congestive heart failure2017

    • Author(s)
      Sano M, Homma T, Ishige T, Sawada N, Ihara S, Kinoshita K, Masuda S, Hao H
    • Journal Title

      Pathol Int

      Volume: 67 Issue: 2 Pages: 110-112

    • DOI

      10.1111/pin.12491

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Proposed Set of Metrics to Reduce Patient Safety Risk From Within the Anatomic Pathology Laboratory2017

    • Author(s)
      Banks P, Brown R, Laslowski A, Daniels Y, Branton P, Carpenter J, Zarbo R, Forsyth R, Liu Yh, Kohl S, Diebold J, Masuda S, Plummer T, Dennis E
    • Journal Title

      Lab Medicine

      Volume: 48 Issue: 2 Pages: 195-201

    • DOI

      10.1093/labmed/lmw068

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maxillary sinus hemangioma: usefulness of embolization according to classification2017

    • Author(s)
      Hasegawa H, Matsuzaki H, Furusaka T, Osimi T, Masuda S, Unno T, Abe O
    • Journal Title

      Brazilian Journal of Otorhinolaryngology

      Volume: 83 Issue: 4 Pages: 490-493

    • DOI

      10.1016/j.bjorl.2015.09.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case Report of Non-Small Cell Lung Cancer with STRN-ALK Translocation:A nonresponder to Alectinib2017

    • Author(s)
      Nakanishi Y, Masuda S, Iida Y, Takahashi N, Hashimoto S
    • Journal Title

      Journal of Thoracic Oncology

      Volume: 12 Issue: 12 Pages: e202-e204

    • DOI

      10.1016/j.jtho.2017.08.009

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in tumor expression of HER2 and hormone receptors status after neoadjuvant chemotherapy in 21 755 patients from the Japanese breast cancer registry2016

    • Author(s)
      Niikura N, Sakatani T, Arima N, Ohi Y, Honma N, Kanomata N, Yoshida K, Kadoya T, Tamaki K, Kumaki N et al:
    • Journal Title

      Annals of oncology

      Volume: 27(3) Issue: 3 Pages: 480-487

    • DOI

      10.1093/annonc/mdv611

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive prognostic report of the Japanese Breast Cancer Society Registry in 2004.2016

    • Author(s)
      Kinoshita T, Fukui N, Anan K, Iwamoto T, Niikura N, Kawai M, Hayashi N, Tsugawa K, Aogi K, Ishida T, Masuoka H, Masuda S, Iijima K, Nakamura S, Tokuda Y.
    • Journal Title

      Breast Cancer

      Volume: 23 Issue: 1 Pages: 39-49

    • DOI

      10.1007/s12282-015-0644-5

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Comprehensive prognostic report of the Japanese Breast Cancer Society Registry in 2005.2016

    • Author(s)
      Anan K, Fukui N, Kinoshita T, Iwamoto T, Niikura N, Kawai M, Hayashi N, Tsugawa K, Aogi K, Ishida T, Masuoka H, Masuda S, Iijima K, Nakamura S, Tokuda Y
    • Journal Title

      Breast Cancer

      Volume: 23 Issue: 1 Pages: 50-61

    • DOI

      10.1007/s12282-015-0645-4

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comprehensive prognostic report of the Japanese Breast Cancer Society registry in 20062016

    • Author(s)
      Iwamoto T, Fukui N, Kinoshita T, Anan K, Niikura N, Kawai M, Hayashi N, Tsugawa K, Aogi K, Ishida T, Masuoka H, Masuda S, Iijima K, Nakamura S, Tokuda Y
    • Journal Title

      Breast Cancer

      Volume: 23 Issue: 1 Pages: 62-72

    • DOI

      10.1007/s12282-015-0646-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Body mass index and survival after diagnosis of invasive breast cancer: a study based on the Japanese National Clinical Database-Breast Cancer Registry.2016

    • Author(s)
      Kawai M, Tomotaki A, Miyata H, Iwamoto T, Niikura N, Anan K, Hayashi N, Aogi K, Ishida T, Masuoka H, Iijima K, Masuda S, Tsugawa K, Kinoshita T, Nakamura S, Tokuda Y
    • Journal Title

      Cancer Medicine

      Volume: 5 Issue: 6 Pages: 1328-1340

    • DOI

      10.1002/cam4.678

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distinct breast cancer characteristics between screen- and self-detected breast cancers recorded in the Japanese Breast Cancer Registry.2016

    • Author(s)
      Iwamoto T, Kumamaru H, Miyata H, Tomotaki A, Niikura N, Kawai M, Anan K, Hayashi N, Masuda S, Tsugawa K, Aogi K, Ishida T, Masuoka H, Iijima K, Matsuoka J, Doihara H, Kinoshita T, Nakamura S, Tokuda Y
    • Journal Title

      Breast Cancer Research and Treatment

      Volume: 156 Issue: 3 Pages: 485-494

    • DOI

      10.1007/s10549-016-3770-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] p62 Regulates the Proliferation of Molecular Apocrine Breast Cancer Cells2016

    • Author(s)
      Nozaki F, Hirotani Y, Nkanishi Y, Yamaguchi H, Nisimaki H, Noda H, Tang X, Yamamoto H, Suzuki A, Seki T, Masuda S
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 49 Issue: 4 Pages: 125-130

    • DOI

      10.1267/ahc.16013

    • NAID

      130005262537

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Roles of Ras Homolog A in Invasive Ductal Breast Carcinoma.2016

    • Author(s)
      Murakami E, Nakanishi Y, Hirotani Y, Ohni S, Tang X, Masuda S, Enomoto K, Sakurai K, Amano S, Ymada T, Nemoto N :
    • Journal Title

      Acta Histochemica et Cytochemica

      Volume: 49 Pages: 125-130

    • NAID

      130005276907

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adenomyoepithelioma with carcinoma of the breast: A report of two cases and a review of the literature.2016

    • Author(s)
      Jing Wu, Tang X, Iida Y, Fuchinoue F, Kusumi T, Yagihashi N, Kawachi K, Shimizu S, Masuda S
    • Journal Title

      Pathology Research and Practice

      Volume: 212 Issue: 2 Pages: 130-134

    • DOI

      10.1016/j.prp.2015.09.008

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors: a study from the Japanese Breast Cancer Registry.2016

    • Author(s)
      Kataoka A, Iwamoto T, Tokunaga E, Tomotaki A, Kumamaru H, Miyata H, Niikura N, Kawai M, Anan K, Hayashi N, Masuda S, Tsugawa K, Aogi K, Ishida T, Masuoka H, Iijima K, Kinoshita T, Nakamura S, Tokuda Y
    • Journal Title

      Breast Cancer Research and Treatment

      Volume: 160 Issue: 1 Pages: 163-172

    • DOI

      10.1007/s10549-016-3984-8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Histopathological characteristics of breast ductal carcinoma in situ and association with imaging findings.2015

    • Author(s)
      Tang X, Yamashita T, Hara M, Kumaki N, Tokuda Y, Masuda S.
    • Journal Title

      Breast Cancer

      Volume: 印刷中 Issue: 3 Pages: 491-498

    • DOI

      10.1007/s12282-015-0592-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathological examination of breast cancer biomarkers: current status in Japan.2015

    • Author(s)
      Masuda S
    • Journal Title

      Breast Cancer

      Volume: 印刷中 Issue: 4 Pages: 485-494

    • DOI

      10.1007/s12282-014-0566-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Altered intracellular region of MUC1 and disrupted correlation of polarity-related molecules in breast cancer subtypes.2015

    • Author(s)
      Iizuka M, Nakanishi Y, Fuchinoue F, Maeda T, Murakami E, Obana Y, Enomoto K, Tani M, Sakurai K, Amano S, Masuda S
    • Journal Title

      Cancer Sci

      Volume: 106 Pages: 307-314

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of PGC1α and accumulation of p62 in apocrine carcinoma of the breast.2015

    • Author(s)
      Fuchinoue F, Hirotani Y, Nakanishi Y, Yamaguchi H, Nishimaki H, Noda H, Tang X, Iiuzuka M, Amano S, Sugitani M, Nemoto N, Masuda S
    • Journal Title

      Pathol. Int.

      Volume: 65 Pages: 19-26

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ホルマリン固定パラフィン包埋組織からのRAS 遺伝子変異検査の検討2017

    • Author(s)
      中西陽子, 関利美, 西巻はるな, 野田博子, 唐小燕, 楠美嘉晃, 東風貢, 高山忠利, 杉谷雅彦, 増田しのぶ
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 乳管癌小葉癌併存症例の分枝系統樹解析2017

    • Author(s)
      野田博子, 江角眞理子, 山口裕美, 増田しのぶ
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 乳腺小葉癌におけるCDH-1 遺伝子異常の検討2017

    • Author(s)
      唐小燕, 中西陽子, 野田博子, 西巻はるな, 楠美嘉晃, 増田しのぶ
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 乳癌の組織型分類と細胞診(ワークショップ2:乳腺腫瘍のWHO組織診断分類と細胞診)2017

    • Author(s)
      増田しのぶ
    • Organizer
      第58回日本組織細胞化学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 1.はじめに:規約改正のコンセプト、3.乳腺腫瘍の組織型分類改訂(案)について 取り扱い規約委員会 公聴会2017

    • Author(s)
      増田しのぶ
    • Organizer
      第25回日本乳癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 病理と遺伝子研究(シンポジウム13 乳癌のバイオロジーと病理)2017

    • Author(s)
      増田しのぶ
    • Organizer
      第25回日本乳癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 髄様癌と鑑別を要した一例2017

    • Author(s)
      増尾有紀, 谷眞弓, 後藤洋伯, 安達慶太, 鈴木周平, 小関淳, 絹川典子, 天野定雄, 逸見明博, 増田しのぶ, 櫻井健一
    • Organizer
      第25回日本乳癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 乳癌細胞における発生・進展における転写因子 E2F-5 の役割の検討2017

    • Author(s)
      稲垣喜則, 藤原恭子, 相馬正義, 尾崎俊文, 増田しのぶ
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 乳癌組織型分類について(教育講演)2017

    • Author(s)
      増田しのぶ
    • Organizer
      第50回東京都細胞検査士会学術研修会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ミトコンドリアDNA多型と癌関連遺伝子体細胞突然変異解析を併用した乳管癌小葉癌併存症例の分子系統樹解析.2016

    • Author(s)
      野田博子, 江角眞理子, 山口裕美, 中井登紀子, 唐小燕, 増田しのぶ
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台、仙台国際センター
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] ミトコンドリア DNA 多型とComprehensive Cancer Panelを併用した乳管癌小葉癌併存症例の分枝系統樹解析2016

    • Author(s)
      野田博子、江角眞理子、山口裕美、中井登紀子、増田しのぶ
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Year and Date
      2016-05-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 乳腺乳管癌と小葉癌併存症例の分子系統樹解析:FFPE/レーザーマイクロ大セクションサンプルのミトコンドリアDNA多型から2015

    • Author(s)
      野田博子、江角眞理子、山口裕美、増田しのぶ
    • Organizer
      第74回日本癌学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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