| Project/Area Number |
15K08360
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Dokkyo Medical University (2016-2017)
Chiba University (2015) |
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Principal Investigator |
YAZAWA TAKUYA 獨協医科大学, 医学部, 教授 (50251054)
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| Co-Investigator(Kenkyū-buntansha) |
原 由紀子 東京医科大学, 医学部, 准教授 (40313267)
矢澤 華子 (佐藤 / 佐藤 華子) 獨協医科大学, 医学部, 講師 (60438132)
三好 洋 聖マリアンナ医科大学, 医学部, 助手 (80322519)
|
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 肺癌 / 神経内分泌肺癌 / 非神経内分泌肺癌 / 形質転換 / 遺伝子治療 / 神経内分泌形質 / 非神経内分泌癌 / 神経内分泌癌 / リプログラミング現象 |
|---|
| Outline of Final Research Achievements |
We had experienced that POU3F4 or POU4F2 transgene made non-neuroendocrine lung cancer (NNELC) cells cause transformation to neuroendocrine lung cancer (NELC). Carrying out this study, it was clarified that the transformation from NNELC to NELC is a direct reprogramming phenomenon and that breakdown of a neural cell-specific NOTCH-HES pathway, which is activated by POU3F4/4F2 transgene, diminish neuroendocrine phenotype.
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