• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Carcinogenesis and progression of high grade EGFR-mutated lung adenocarcinoma

Research Project

Project/Area Number 15K08365
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionYokohama City University

Principal Investigator

OHASHI Kenichi  横浜市立大学, 医学研究科, 教授 (40231203)

Co-Investigator(Kenkyū-buntansha) 奥寺 康司  横浜市立大学, 医学部, 准教授 (10326027)
立石 陽子  横浜市立大学, 医学部, 助教 (20644438)
梅田 茂明  横浜市立大学, 医学部, 助教 (30644439)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords肺がん / 腺がん / 病理学 / EGFR / 間質性肺炎 / 粘液 / 病理 / 肺癌 / 腺癌 / 転移
Outline of Final Research Achievements

Surgically resected lung adenocarcinomas with and without lymph node metastasis and biopsy samples from inoperably advanced tumors were examined pathologically. The micropapillary element was clarified to be an exclusive determinant of malignant potential in EGFR-mutated lung adenocarcinomas.
Pathological features and mucin family protein expression profile of idiopathic interstitial pneumonia (IIP)-associated pulmonary adenocarcinomas was investigated. In the IIP group, expression of MUC1, MUC7 and MUC21 was lower, and that of MUC4, MUC5AC, MUC5 and MUC9 was higher than non-IIP group. In the TRU group cases, IIP group cases showed distinctly lower expression of MUC1, and higher expression of MUC4, MUC5B and MUC9 than non-IIP group cases. Expression of MUC21 was tightly linked to micropapillary and low papillary lepidic variants.IIP-associated pulmonary adenocarcinomas, especially those of TRU group, showed specific expression profile of mucin family proteins.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (30 results)

All 2018 2017 2016 2015 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 9 results,  Acknowledgement Compliant: 6 results) Presentation (15 results) Remarks (1 results)

  • [Journal Article] Relationship between non-TRU lung adenocarcinomas and bronchiolar metaplasia - potential implication in their histogenesis2018

    • Author(s)
      Okudela K, Kojima Y, Matsumura M, Arai H, Umeda S, Tateishi Y, Mitsui H, Suzuki T, Tajiri M, Ogura T, Ohashi K.
    • Journal Title

      Histol Histopathol

      Volume: 33 Pages: 317-326

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Update on the potential significance of psammoma bodies in lung adenocarcinoma from a modern perspective2018

    • Author(s)
      3.Miyake A, Okudela K, Matsumura M, Hideaki M, Arai H, Umeda S, Yamanaka S, Ishikawa Y, Tajiri M, Ohashi K
    • Journal Title

      Histopathology

      Volume: 72 Issue: 4 Pages: 609-618

    • DOI

      10.1111/his.13397

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The potential significance of alpha-enolase (ENO1) in lung adenocarcinomas - A utility of the immunohistochemical expression in pathologic diagnosis.2017

    • Author(s)
      Okudela K, Mitsui H, Matsumura M, Arai H, Shino K, Sekine A, Woo T, Suzuki T, Ishikawa Y, Umeda S, Tajiri M, Masuda M, Ohashi K.
    • Journal Title

      Pathol Int.

      Volume: 67(12) Issue: 12 Pages: 602-609

    • DOI

      10.1111/pin.12607

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low body surface area predicts hepatotoxicity of nintedanib in patients with idiopathic pulmonary fibrosis2017

    • Author(s)
      4.Ikeda S, Sekine A, Baba T, Yamanaka Y, Sadoyama S, Yamakawa H, Oda T, Okuda R, Kitamura H, Okudela K, Iwasawa T, Ohashi K, Takemura T, Ogura T.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 10811-10811

    • DOI

      10.1038/s41598-017-11321-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isolated Brain Metastases as the First Relapse After the Curative Surgical Resection in Non-Small-Cell Lung Cancer Patients With an EGFR Mutation2017

    • Author(s)
      5.Sadoyama S, Sekine A, Satoh H, Iwasawa T, Kato T, Ikeda S, Sata M, Baba T, Tabata E, Minami Y, Nemoto K, Hayashihara K, Saito T, Okudela K, Ohashi K, Tajiri M, Ogura T
    • Journal Title

      Clin Lung Cancer

      Volume: 19 Issue: 1 Pages: e29-e36

    • DOI

      10.1016/j.cllc.2017.05.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The pathological features of idiopathic interstitial pneumonia-associated2017

    • Author(s)
      Kojima Y, Okudela K, Matsumura M, Omori T, Baba T, Sekine A, Woo T, Umeda S, Takemura T, Mitsui H, , Suzuki T, Tateishi Y, Iwasawa T, Arai H, Tajiri M, Ogura T, Kameda Y, Masuda M, Ohashi K
    • Journal Title

      Histopathology

      Volume: 70 Issue: 4 Pages: 568-578

    • DOI

      10.1111/his.13103

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Histopathological Feature of EGFR-Mutated Lung Adenocarcinomas with Highly Malignant Potential - An Implication of Micropapillary Element.2016

    • Author(s)
      Matsumura M, Okudela K, Kojima Y, Umeda S, Tateishi Y, Sekine A, Arai H, Woo T, Tajiri M, Ohashi K
    • Journal Title

      PloS one

      Volume: 11 Issue: 11 Pages: e0166795-e0166795

    • DOI

      10.1371/journal.pone.0166795

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of tropomyosins in lung cancer - a potential role in carcinogenesis and its utility in a histopathological diagnosis2016

    • Author(s)
      Okudela K, Mitsui H, Woo T, Kojima Y, Matsumura M, Arai H, Suzuki T, Umeda S, Tateishi Y, Saito Y, Tajiri M, Masuda M, Kameda Y, Ohashi K
    • Journal Title

      Histology and histopathology

      Volume: 31 Pages: 857-866

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alterations in cathepsin L expression in lung cancers2016

    • Author(s)
      Okudela K, Mitsui H, Woo T, Arai H, Suzuki T, Matsumura M, Kojima Y, Umeda S, Tateishi Y, Masuda M, Ohashi K
    • Journal Title

      Pathology international

      Volume: 66 Issue: 7 Pages: 386-392

    • DOI

      10.1111/pin.12424

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intraosseous inflammatory myofibroblastic tumor of the mandible with a novel ATIC-ALK fusion mutation: a case report2016

    • Author(s)
      Tateishi Y, Okudela K, Kawai S, Suzuki T, Umeda S, Matsumura M, Kioi M, Ohashi K
    • Journal Title

      Diagnostic pathology

      Volume: 11 Pages: 132-132

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Up-Regulation of S100A11 in Lung Adenocarcinoma - Its Potential Relationship with Cancer Progression2015

    • Author(s)
      Woo T, Okudela K, Mitsui H, Tajiri M, Rino Y, Ohashi K, Masuda M
    • Journal Title

      PloS one

      Volume: 10

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinicopathologic study of intestinal spirochetosis in Japan with special reference to human immunodeficiency virus infection status and species types: analysis of 5265 consecutive colorectal biopsies2015

    • Author(s)
      Tateishi Y, Takahashi M, Horiguchi S, Funata N, Koizumi K, Okudela K, Hishima T, Ohashi K
    • Journal Title

      BMC infectious diseases

      Volume: 15 Pages: 13-13

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The potential role of microRNA-31 expression in early colorectal cancer2015

    • Author(s)
      Tateishi Y, Okudela K, Mitsui H, Umeda S, Suzuki T, Kojima Y, Watanabe K, Kawano N, Endo I, Ohashi K
    • Journal Title

      Pathology international

      Volume: 65 Pages: 513-518

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Leptomeningeal melanomatosis associated with neurocutaneous melanosis: an autopsy case report2015

    • Author(s)
      Matsumura M, Okudela K, Tateishi Y, Umeda S, Mitsui H, Suzuki T, Nakayama T, Inayama Y, Ohashi K
    • Journal Title

      Pathology international

      Volume: 65 Pages: 100-105

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 高悪性度のEGFR変異型肺腺癌の組織病理学的特性2017

    • Author(s)
      松村 舞依, 奥寺 康司, 小島 陽子, 梅田 茂明, 立石 陽子, 三井 秀昭, 鈴木 健久, 荒井 宏雅, 関根 朗雅, 大橋 健一
    • Organizer
      日本病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肺の繊毛性粘液結節性乳頭状腫瘍の3例に関する臨床病理学的な研究2017

    • Author(s)
      片岡 俊朗, 奥寺 康司, 澤住 知枝, 梅田 茂明, 山中 正二, 石川 善啓, 荒井 宏雅, 田尻 道彦, 大橋 健一
    • Organizer
      日本病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肺腺がんにおいてIL-24の発現損失は浸潤を促進する2017

    • Author(s)
      梅田 茂明、奥寺 康司, 小島 陽子, 三井 秀昭, 立石 陽子, 鈴木 健久, 松村 舞依, 斎藤 悠一, 大橋 健一
    • Organizer
      日本病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肺腺がんの組織形成に細気管支の異形成が関与する可能性2017

    • Author(s)
      奥寺康司, 小島 陽子, 松村 舞依, 梅田 茂明, 立石 陽子, 荒井 宏雅, 関根 朗雅, 大橋 健一
    • Organizer
      日本病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 間質性肺炎に合併する肺癌の病理組織学的検討2016

    • Author(s)
      小島 陽子, 奥寺 康司, 松村 舞依, 梅田 茂明, 立石 陽子, 田尻 道彦, 小倉 高志, 武村 民子, 益田 宗孝, 大橋 健一
    • Organizer
      病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] miR-31およびmiR-21は早期大腸癌において発現が亢進している2016

    • Author(s)
      立石 陽子, 奥寺 康司, 三井 秀昭, 梅田 茂明, 松村 舞衣, 小島 陽子, 河野 尚美, 稲山 嘉明, 大橋 健一
    • Organizer
      日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] 砂粒体を有する肺腺癌の臨床病理学的特性2016

    • Author(s)
      三宅 暁夫, 梅田 茂明, 立石 陽子, 奥寺 康司, 荒井 宏雅, 大橋 健一:
    • Organizer
      日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] 肺腺癌におけるカテプシンLの発現2016

    • Author(s)
      奥寺 康司, 三井 秀昭, 鈴木 健久, 禹 哲漢, 荒井 宏雅, 梅田 茂明, 立石 陽子, 大橋 健一
    • Organizer
      日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] 腎臓に発生したSuccinate dehydrogenase B-deficient Renal Cell Carcinomaの1例2016

    • Author(s)
      岩下 広道, 澤住 知枝, 江中 牧子, 宇高 直子, 三宅 暁夫, 日比谷 孝志, 山中 正二, 大橋 健一, 八尾 正祐, 長嶋 洋治
    • Organizer
      日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] 唾液腺腺房細胞癌の再検討 MASCの可能性について2016

    • Author(s)
      片岡 俊朗, 岩下 広道, 澤住 知枝, 江中 牧子, 三宅 暁夫, 日比谷 孝志, 宇高 直子, 山中 正二, 長尾 俊孝, 大橋 健一
    • Organizer
      日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] Expression of tropomyosin in lung cancer potential role in lung carcinogenesis2015

    • Author(s)
      奥寺康司, 立石陽子, 梅田茂明, 禹哲漢, 田尻道彦, 大橋健一
    • Organizer
      日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 肺腺腫におけるIL-24の腫瘍抑制的な役割2015

    • Author(s)
      梅田 茂明, 奥寺 康司, 三井 秀昭, 鈴木 健久, 立石 陽子, 小島 陽子, 松村 舞依, 大橋 健一
    • Organizer
      日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 高悪性度EGFR変異型肺腺癌の病理組織学的特性2015

    • Author(s)
      松村 舞依, 奥寺 康司, 小島 陽子, 梅田 茂明, 立石 陽子, 三井 秀昭, 鈴木 健久, 大橋 健一
    • Organizer
      日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 下顎骨に発生したInflammatory myofibroblastic tumorの1例2015

    • Author(s)
      立石 陽子, 奥寺 康司, 河合 繁夫, 比島 恒和, 梅田 茂明, 松村 舞衣, 小島 陽子, 齋藤 悠一, 来生 知, 大橋 健一
    • Organizer
      日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 間質性肺炎に合併する肺癌の病理組織学的検討2015

    • Author(s)
      小島 陽子, 奥寺 康司, 松村 舞依, 梅田 茂明, 立石 陽子, 田尻 道彦, 小倉 高志, 益田 宗孝, 大橋 健一
    • Organizer
      日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
  • [Remarks] 横浜市立大学医学部病態病理学教室ホームページ

    • URL

      http://www-user.yokohama-cu.ac.jp/~pathola/index.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi