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Studies on biological properties of cancer stem cells in malignant mesothelioma

Research Project

Project/Area Number 15K08370
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionHyogo Medical University

Principal Investigator

Sato Ayuko  兵庫医科大学, 医学部, 講師 (20419823)

Co-Investigator(Kenkyū-buntansha) 辻村 亨  兵庫医科大学, 医学部, 教授 (20227408)
篠原 義康  兵庫医科大学, 医学部, 助教 (60723509)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords悪性中皮腫 / がん幹細胞
Outline of Final Research Achievements

It is thought that cancer stem cells in malignant mesothelioma, mesothelioma stem cells, are involved in the resistance to treatment of malignant mesothelioma. When reprogramming factors for induced pluripotent stem cells were introduced into mesothelioma cell lines, colony forming cells appeared. The colony forming cells showed increase of spheroid formation, reduction of proliferation, and increase of resistance to an anticancer drug. In addition, in the colony forming cells, a cell adhesion molecule, which was found as a candidate for mesothelioma stem cell related factor by analyses of tumor specimens from recurrent malignant pleural mesothelioma, was more strongly expressed. Since these cells introduced with reprogramming factors showed characteristics as cancer stem cells, they may be useful to develop new diagnosis and therapy targeting mesothelioma stem cells.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (24 results)

All 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (16 results) (of which Int'l Joint Research: 3 results) Book (1 results)

  • [Journal Article] A combination of MTAP and BAP1 immunohistochemistry in pleural effusion cytology for the diagnosis of mesothelioma2017

    • Author(s)
      Kinoshita Yoshiaki、Hida Tomoyuki、Hamasaki Makoto、Matsumoto Shinji、Sato Ayuko、Tsujimura Tohru、Kawahara Kunimitsu、Hiroshima Kenzo、Oda Yoshinao、Nabeshima Kazuki
    • Journal Title

      Cancer Cytopathology

      Volume: 126 Issue: 1 Pages: 54-63

    • DOI

      10.1002/cncy.21928

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemical detection of MTAP and BAP1 protein loss for mesothelioma diagnosis: Comparison with 9p21 FISH and BAP1 immunohistochemistry.2017

    • Author(s)
      Hida T, Hamasaki M, Matsumoto S, Sato A, Tsujimura T, Kawahara K, Iwasaki A, Okamoto T, Oda Y, Honda H, Nabeshima K.
    • Journal Title

      Lung Cancer

      Volume: 104 Pages: 98-105

    • DOI

      10.1016/j.lungcan.2016.12.017

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Usefulness of p16/CDKN2A fluorescence in situ hybridization and BAP1 immunohistochemistry for the diagnosis of biphasic mesothelioma.2017

    • Author(s)
      Wu D, Hiroshima K, Yusa T, Ozaki D, Koh E, Sekine Y, Matsumoto S, Nabeshima K, Sato A, Tsujimura T, Yamakawa H, Tada Y, Shimada H, Tagawa M.
    • Journal Title

      Ann Diagn Pathol.

      Volume: 26 Pages: 31-37

    • DOI

      10.1016/j.anndiagpath.2016.10.010

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma.2016

    • Author(s)
      Yoshikawa Y, Emi M, Hashimoto-Tamaoki T, Ohmuraya M, Sato A, Tsujimura T, Hasegawa S, Nakano T, Nasu M, Pastorino S, Szymiczek A, Bononi A, Tanji M, Pagano I, Gaudino G, Napolitano A, Goparaju C, Pass HI, Yang H, Carbone M.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 113 Issue: 47 Pages: 13432-13437

    • DOI

      10.1073/pnas.1612074113

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] BAP1 immunohistochemistry and p16 FISH results in combination provide higher confidence in malignant pleural mesothelioma diagnosis: ROC analysis of the two tests.2016

    • Author(s)
      Hida T, Hamasaki M, Matsumoto S, Sato A, Tsujimura T, Kawahara K, Iwasaki A, Okamoto T, Oda Y, Honda H, Nabeshima K.
    • Journal Title

      Pathol Int

      Volume: 66 Issue: 10 Pages: 563-570

    • DOI

      10.1111/pin.12453

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low homozygous/high heterozygous deletion status by p16 FISH correlates with a better prognostic group than high homozygous deletion status in malignant pleural mesothelioma.2016

    • Author(s)
      Hamasaki M, Matsumoto S, Abe S, Hamatake D, Kamei T, Hiroshima K, Kawahara K, Sato A, Tsujimura T, Nakatani Y, Yoshida Y, Iwasaki A, Nabeshima K.
    • Journal Title

      Lung Cancer

      Volume: 99 Pages: 155-161

    • DOI

      10.1016/j.lungcan.2016.07.011

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Frequent genomic rearrangements of BRCA1 associated protein-1 (BAP1) gene in Japanese malignant mesothelioma-characterization of deletions at exon level.2015

    • Author(s)
      Emi M et al
    • Journal Title

      J Hum Genet

      Volume: 60 Issue: 10 Pages: 647-649

    • DOI

      10.1038/jhg.2015.91

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 悪性胸膜中皮腫の診断におけるBAP1免疫染色の有用性の検討2017

    • Author(s)
      佐藤鮎子,篠原義康,阿部晋也,鍋島一樹,辻村 亨
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 悪性中皮腫細胞株におけるヒドロキシクロロキンの細胞致死効果についての検討2017

    • Author(s)
      篠原義康,佐藤鮎子,阿部晋也,辻村亨
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 中皮腫診断の最前線2017

    • Author(s)
      鍋島一樹,木下義晃,松本慎二,樋田知之,佐藤鮎子,辻村 亨,河原邦光,廣島健三,亀井敏昭,小田 義直
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 243症例の悪性胸膜中皮腫の統合的ゲノム解析2017

    • Author(s)
      竹下純平, 山本尚吾, 辰野健二, 白石友一, 大搗泰一郎, 栗林康造, 近藤展行, 長谷川誠紀, 佐藤鮎子, 辻村亨, 中野孝司, 関戸好孝, 油谷浩幸
    • Organizer
      第76回日本癌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫の胸水細胞診におけるBAP1免疫染色の有用性2017

    • Author(s)
      辻村 亨,佐藤鮎子,隅田安由美,篠原義康,阿部晋也
    • Organizer
      第58 回日本臨床細胞学会総会春期大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 中皮腫の早期診断に役立つp16 FISHとBAP1, MTAP免疫染色2017

    • Author(s)
      鍋島一樹,木下義晃,松本慎二,樋田知之,佐藤鮎子,辻村 亨,河原邦光,廣島健三,亀井敏昭,小田義直
    • Organizer
      第58回日本臨床細胞学会総会春期大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Utility of liquid-based cytology in the diagnosis of malignant pleural mesothelioma2016

    • Author(s)
      Tsujimura T, Sato A, Shinohara Y, Sumida A, Nakanishi T, Sato G, Ishida M, Torii Y, Shimizu S.
    • Organizer
      The 19th International Congress of Cytology
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-05-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical, cytological, and molecular biological approaches to the diagnosis of early mesothelioma2016

    • Author(s)
      Tsujimura T, Sato A, Shinohara Y, Sumida A, Hasegawa S, Nakano T.
    • Organizer
      The 19th International Congress of Cytology
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-05-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 悪性胸膜中皮腫における液状化検体細胞診の有用性の検討2016

    • Author(s)
      佐藤鮎子, 篠原義康, 清水重喜, 隅田安由美, 中野孝司, 長谷川誠紀, 鍋島一樹, 辻村 亨
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 悪性中皮腫細胞株におけるオートファジーの役割2016

    • Author(s)
      篠原義康, 佐藤鮎子, 隅田安由美, 辻村 亨
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] Relationship of PD-L1 Expression and Prognosis in Epithelioid Mesothelioma2016

    • Author(s)
      Tsujimura T, Kudo T, Shinohara Y, Sato A, Shimizu S, Daimon T, Hasegawa S, Nakano T.
    • Organizer
      13th International Conference of the International Mesothelioma Interest Group
    • Place of Presentation
      Birmingham, UK
    • Year and Date
      2016-05-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] NF2遺伝子関連蛋白Merlinの染色性と中皮腫の腫瘍特性の関連2015

    • Author(s)
      栗林康造, 家城隆次, 大搗泰一郎, 金村晋吾, 柴田英輔, 政近江利子, 神谷 瞳, 三上浩司, 寺田貴普, 近藤展行, 佐藤鮎子, 清水重喜, 長谷川誠紀, 辻村 亨, 中野孝司
    • Organizer
      第56回日本肺癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 中皮腫診断の現状と将来2015

    • Author(s)
      辻村 亨, 佐藤鮎子, 篠原義康, 工藤朝雄, 今橋祐喜, 清水重喜, 鍋島一樹, 長谷川誠紀, 中野孝司
    • Organizer
      第56 回日本臨床細胞学会総会春期大会
    • Place of Presentation
      松江テルサ(松江)
    • Year and Date
      2015-06-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 胸水検体を用いた悪性胸膜中皮腫の分子病理学的診断法の検討2015

    • Author(s)
      佐藤鮎子,篠原義康,工藤朝雄,今橋祐喜,中野孝司,長谷川誠紀,辻村亨
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 悪性中皮腫における上皮間葉転換分子TWIST1の生物学的作用2015

    • Author(s)
      篠原義康,佐藤鮎子,工藤朝雄,今橋祐喜,中野孝司,長谷川誠紀,辻村亨
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 悪性胸膜中皮腫におけるPD-L1発現と予後との関連性2015

    • Author(s)
      工藤朝雄,今橋祐喜,佐藤鮎子,篠原義康,鍋島一樹,中野孝司,長谷川誠紀,辻村亨
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
  • [Book] 石綿関連疾患の病理とそのリスクコミュニケーション2015

    • Author(s)
      清水重喜,鳥井郁子,佐藤鮎子,辻村 亨
    • Total Pages
      300
    • Publisher
      篠原出版新社
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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