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Pathogenesis of lung adenocarcinoma based on lung fibrosis

Research Project

Project/Area Number 15K08372
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

Matsubara Osamu  公益財団法人がん研究会, がん研究所 病理部, 研究員 (40107248)

Co-Investigator(Kenkyū-buntansha) 石川 雄一  公益財団法人がん研究会, がん研究所 病理部, 部長 (80222975)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords肺腺癌 / 異型腺腫様過形成 / 上皮内腺癌 / 微小浸潤性腺癌 / 置換型腺癌 / 肺線維症 / 間質性肺炎 / 肺胞の細気管支化 / 肺線がん / adenocarcinoma in situ / 異型腺腫様増生
Outline of Final Research Achievements

We consider that progressive steps of lung adenocarcinoma may start from proliferation of bronchiolar epitheli, to atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), to minimally invasive adenocarcinoma, finally to lepidic pattern adenocarcinoma, and examined and compared the clinic-pathological features of resected operation materials of lung adenocarcinoma with lung fibrosis/interstitial pneumonia and without lung fibrosis/interstitial pneumonia. Of over all the materials of lung adenocarcinoma, lung fibrosis/interstitial pneumonia was found in 20.6%, AAH in 23.6%, multiple cancers in 13.2%, and bronchiolization of alveoli in 23.5%. AAH and bronchiolization of alveoli were significantly more observed in lung adenocarcinoma with lung fibrosis/interstitial pneumonia. This finding suggest lung fibrosis and bronchiolization of alveoli may have an important role.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (19 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 10 results,  Invited: 6 results)

  • [Journal Article] Expanded acceptance of acute exacerbation of nonspecific interstitial pneumonia, including 7 additional cases with detailed clinical pathologic correlation2018

    • Author(s)
      Miyamoto A, Sharma A, Nishino M, Mino-Kenudson M, Matsubara O, Mark EJ
    • Journal Title

      Pathol Int [Epub ahead of print]

      Volume: 123 Issue: 7 Pages: 401-408

    • DOI

      10.1111/pin.12676

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hypersensitivity Pneumonitis A Perspective From Members of the Pulmonary Pathology Society2018

    • Author(s)
      Miller R, Allen TC, Barrios RJ, Beasley MB, Burke L, Cagle PT, Capelozzi VL, Ge Y, Hariri LP, Kerr KM, Khoor A, Larsen BT, Mark EJ, Matsubara O, Mehrad M, Mino-Kenudson M, Raparia K, Roden AC, Russell P, Schneider F, Sholl LM, Smith ML
    • Journal Title

      Arch Pathol Lab Med

      Volume: 142(1) Issue: 1 Pages: 120-126

    • DOI

      10.5858/arpa.2017-0138-sa

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Case of Squamous Cell Carcinoma in Bladder Diverticulum Producing Granulocyte Colony Stimulating Factor2017

    • Author(s)
      Uemura K, Namura K, Umemoto S, Matsubara O, Udagawa K
    • Journal Title

      泌尿器科紀要

      Volume: 63 Issue: 5 Pages: 211-215

    • DOI

      10.14989/ActaUrolJap_63_5_211

    • NAID

      120006312214

    • ISSN
      0018-1994
    • Year and Date
      2017-05-31
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intratumoral Programmed Cell Death-Ligand 1 (PD-L1) and Intratumoral CD8+ T Cell Expression in Lung Cancer.2017

    • Author(s)
      Jin Y, Matsubara O, et al.
    • Journal Title

      Mod Pathol

      Volume: 2 Pages: 481-481

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Case of Solitary Adrenal Metastasis from Rectal Cancer Treated by Adrenalectomy after Preoperative Chemotherapy.2016

    • Author(s)
      Tsuchida K, Watanabe H,Matsubara O, et al.
    • Journal Title

      癌と化学療法

      Volume: 43 Pages: 1751-1753

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High levels of DJ-1 protein and isoelectric point 6.3 isoform in sera of breast cancer patients2015

    • Author(s)
      Kawate T, Iwaya K, Matsubara O, et al
    • Journal Title

      Cancer Sci

      Volume: 106 Pages: 938-943

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinico-pathological analysis referring hemeoxygenase-1 in acute fibrinous and organizing pneumonia patients2015

    • Author(s)
      Hara Y, Shinkai M, Matsubara O, et al.
    • Journal Title

      Respir Med Case Rep

      Volume: 14 Pages: 53-56

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Cancer Stem Cells of the Lung Adenocarcinoma, Emphasizing the Level during the Progression from Atypical Adenomatous Hyperplasia to Invasive Adenocarcinoma2018

    • Author(s)
      Matsubara1 O, Jin Y, Mark EJ
    • Organizer
      The 107th Annual Meeting of USCAP
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression of Intratumoral Programmed Cell Death-ligand 1 (PD-L1) and Intratumoral CD8+ T Cell and FOXP3+ T Cell in Lung Cancer2018

    • Author(s)
      Jin Y, Imase R, Matsubara O
    • Organizer
      The 107th Annual Meeting of USCAP
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肺癌におけるtumor-associated vasculopathy2017

    • Author(s)
      松原 修、神 靖人、石川雄一.
    • Organizer
      第106回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2017-04-27
    • Related Report
      2016 Research-status Report
  • [Presentation] Intratumoral Programmed Cell Death-Ligand 1 (PD-L1) and Intratumoral CD8+ T Cell Expression in Lung Cancer2017

    • Author(s)
      Jin Y, Matsubara O
    • Organizer
      The 106th Annual Meeting of USCAP
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Update in Pulmonary Vascular Disease.2016

    • Author(s)
      Matsubara O.
    • Organizer
      The 11th Annual Meeting of the Asia Pacific Society for Molecular Immunohistology and the 3rd Annual Conference of the Asia-Australasia Pulmonary Pathology Society
    • Place of Presentation
      台湾、台北
    • Year and Date
      2016-12-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Pulmonary Massive Necrotic Nodule, Case Presentation.2016

    • Author(s)
      Matsubara O.
    • Organizer
      The 6th Taiwan-Japan Conjoint Slide Conference
    • Place of Presentation
      名古屋
    • Year and Date
      2016-10-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Bronchiolization of Alveoli in the Progress to Lung Cancer.2016

    • Author(s)
      Matsubara O.
    • Organizer
      The XXXI International Congress of the International Academy of Pathology
    • Place of Presentation
      ドイツ、コロン
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 肺癌におけるTumor-Associated Vasculopathyの意義.2016

    • Author(s)
      松原 修、神 靖人、山仲一輝、石川雄一.
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] Programmed Death 1 (PD-1) and PD-L1 Expression in Lung Adenocarcinoma, with Lower Expression in In Situ and Minimally Invasive Tumors and Higher Expression in Larger and Invasive Tumors2016

    • Author(s)
      Matsubara O, Jin Y, Yamauchi S, et al.
    • Organizer
      The 105th Annual Meeting of USCAP
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2016-03-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Molecular pathology of the lung cancers, targeted therapy and pathologists2015

    • Author(s)
      Matsubara O
    • Organizer
      The 10th Asia Pacific Society for Molecular Immunohistology Conference
    • Place of Presentation
      Yogyakarta, Indonesia
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Adenocarcinoma in situ (AIS) of the lung, relation to bronchiolization of alveoli2015

    • Author(s)
      Matsubara O
    • Organizer
      The 9th Asia Pacific IAP Congress
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Several topics of lung pathology, including early lung cancer2015

    • Author(s)
      Matsubara O
    • Organizer
      The Third Regional Pathology Symposium
    • Place of Presentation
      Fiji
    • Year and Date
      2015-05-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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