Quantative analysis of nuclear shape and chromatin distribution in endometrial cancer, hyperplasia and metaplasia
| Project/Area Number |
15K08378
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大喜 雅文 九州大学, 医学研究院, 教授 (10160441)
園田 顕三 九州大学, 医学研究院, 准教授 (30294929)
杉島 節夫 九州大学, 医学研究院, 教授 (50380382)
渡邊 壽美子 九州大学, 医学研究院, 助教 (90404087)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 子宮内膜癌 / 子宮内膜過形成 / 子宮内膜上皮化生 / クロマチン分布 / 扁平上皮化生 / 二核細胞 / 子宮内膜扁平上皮化生 / 子宮内膜増殖症 / 子宮内膜化生 / 核クロマチン分布 / 核中心間最短距離 / 不規則重積性 / 核中心点間最短距離 / 極性の乱れ / 核小体 |
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| Outline of Final Research Achievements |
The presence, extent, and frequency of appearance of nuclear atypia of squamous metaplasia in endometrial carcinoma were examined. In tissue specimens, squamous metaplasia appeared at 58%, and no difference was found between appearance group and non- squamous metaplasia group. Histologically, vascular invasion was highly sophisticated in squamous metaplasia.In the cytologic specimen, squamous metaplasia was observed in 70% of 60 cases with endometrial carcinoma positive, but no nuclear atypia was observed.
In a study using Hela cell, we reported that it induces more binuclear cell formation in 0% medium. When nutrition improvement was carried out, it was suggested that there was something that could restore the ability to divide.
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Report
(4 results)
Research Products
(25 results)
