Nagasaki atomic bomb survivors timor tissue bank and exhaustive analysis of the molecular pathology
| Project/Area Number |
15K08379
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nagasaki University |
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Principal Investigator |
MIURA Shiro 長崎大学, 原爆後障害医療研究所, 講師 (80513316)
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| Co-Investigator(Kenkyū-buntansha) |
吉浦 孝一郎 長崎大学, 原爆後障害医療研究所, 教授 (00304931)
中島 正洋 長崎大学, 原爆後障害医療研究所, 教授 (50284683)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 放射線影響研究 / 放射線発癌 / 原爆被爆者 / 腫瘍組織バンク / 遺伝子不安定性 |
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| Outline of Final Research Achievements |
We have been conducting a cohort study of tissue bank for cancers which were freshly resected from A-bomb survivors together with information on the A-bombing and medical data. To assess the quality of RNA in this biobank, we investigated the level of RNA degradation and its correlation with frozen tissue storage period/yield of extracted RNA in each organ. The quality of extracted RNA in biobank was significantly influenced by storage period, site of tissue, normal/tumor tissues, and yield of extracted RNA, suggesting a necessity of careful quality control in each site of tissue. Furthermore, using nucleic acid extraction DNA, we conducted the exhaustive analysis of A-bomb survivors’ lung cancer by aCGH method. It was shown that short-distance group(<2km from hypocenter) were more size and frequency of the region of gene amplification and the deletion in the tumor region than a long-distance group(≧2km) in each lung adenocarcinoma and squamous cell carcinoma.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Expression of Somatostatin Receptor Type 2A and PTEN in Neuroendocrine Neoplasms Is Associated with Tumor Grade but Not with Site of Origin.2016
Author(s)
Wada H, Matsuda K, Akazawa Y, Yamaguchi Y, Miura S, Ueki N, Kinoshita A, Yoshiura K, Kondo H, Ito M, Nagayasu T, Nakashima M.
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Journal Title
Endocr Pathol.
Volume: 27(3)
Issue: 3
Pages: 179-187
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Association between p53-binding protein 1 expression and genomic instability in oncocytic follicular adenoma of the thyroid2016
Author(s)
Mussazhanova Z, Akazawa Y, Matsuda K, Shichijo K, Miura S, Otsubo R, Oikawa M, Yoshiura K, Mitsutake N, Rogounovitch T, Saenko V, Kozykenova Z, Zhetpisbaev B, Shabdarbaeva D, Sayakenov N, Amntayev B, Kondo H, Ito M, Nakashima M.
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Journal Title
Endocrine Journal
Volume: 63
Issue: 5
Pages: 457-467
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Association between p53-binding protein 1 expression and genomic instability in oncocytic follicular adenoma of the thyroid2016
Author(s)
Mussazhanova Z, Akazawa Y, Matsuda K, Shichijo K, Miura S, Otsubo R, Oikawa M, Yoshiura K, Mitsutake N, Rogounovich T, Saenko V, Kozykenove Z, Zhetpisbaev B, Kondo H, Ito M, Nakashima M
Organizer
第4回日本甲状腺病理学会
Place of Presentation
仙台市立病院 講堂(宮城県・仙台市)
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