| Project/Area Number |
15K08381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kagawa Prefectural College of Health Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
徳原 康哲 愛媛県立医療技術大学, 保健科学部, 講師 (60746329)
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| Co-Investigator(Renkei-kenkyūsha) |
Haba Reiji 香川大学, 医学部・附属病院, 准教授 (90304584)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | claudin / 大腸癌 / 免疫組織化学 / 増殖・浸潤能 / claudinの発現 / 浸潤、転移 |
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| Outline of Final Research Achievements |
The present study investigated the expression and localization of tight-junction-associated protein claudins in colorectal adenocarcinoma tissues and cell lines. The membranous expression of claudin-1 was correlated with lymphatic vessel invasion and depth of tumor invasion, whereas the nuclear expression of claudin-3 was significantly increased in mucinous adenocarcinoma. The expression level of the claudin-1 protein was significantly lower in metastatic colon cancer cell line SW620 cells than in primary colon cancer cell line Caco-2 cells. Up-regulation of claudin-1 expression was associated with cell proliferation and cell migration.
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