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Analysis of VCP and UBL4A involvement in STAT3 signaling

Research Project

Project/Area Number 15K08391
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionInternational University of Health and Welfare (2017-2018)
Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2015-2016)

Principal Investigator

tomita yasuhiko  国際医療福祉大学, 医学部, 教授 (60263266)

Research Collaborator Kubo Chiaki  大阪府立国際がんセンター, 病理・細胞診断科, 医員
Kitamura Masanori  大阪府立国際がんセンター, 病理・細胞診断科, 医員
Kotani Syohta  大阪府立成人病センター, 病理・細胞診断科, 研究員
Kishida Mioka  大阪府立国際がんセンター, 病理・細胞診断科, 医師
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsVCP / UBL4A / STAT3 / 臨床病理学的検討 / NFκB / STAS3 / GdX
Outline of Final Research Achievements

This study was designed to clarify the correlation between VCP and UBL4A in the STAT3 signaling pathway. In the first step, analysis using cell lines was not reproductive. Then, analysis using gene-modified mouse was planned. VCP-conditional KO mouse, VCP-transgenic mouse were successfully made. In addition, clinic-pathologic analysis on cancer development and metastasis was performed.

Academic Significance and Societal Importance of the Research Achievements

VCPとUBL4Aの関連の検討は、モデルマウスの作製が必須と考え、作製には成功したが、研究期間内では、さらなる検討には至らなかった。後続の検討を行い成果を発表していきたい。
そのほか、がんに関する臨床病理学的検討を行い、乳がんのリンパ節転移を検出するOne-step nucleic acid amplification assayの有用性を明らかにし、中咽頭扁平上皮癌のHPV statusと治療効果の関係、食道腺癌のリンパ節転移に関与す因子、EGFR遺伝子変異を伴わない肺腺癌の進展に関与する因子を明らかにした。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2019 2018 2016 2015

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 5 results) Presentation (1 results) Book (2 results)

  • [Journal Article] Performance of a new system using a one-step nucleic acid amplification assay for detecting lymph node metastases in breast cancer.2019

    • Author(s)
      Shimazu K, Tanei T, Tamaki Y, Saeki T, Osaki A, Hasebe T, Tomita Y, Daito M, Kobayashi M, Noguchi S.
    • Journal Title

      Med Oncol

      Volume: 36 Issue: 6 Pages: 54-54

    • DOI

      10.1007/s12032-019-1277-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiotherapy alone as a possible de-intensified treatment for human papillomavirus-related locally advanced oropharyngeal squamous cell carcinoma.2019

    • Author(s)
      Yamamoto Y, Takemoto N, Michiba T, Seo Y, Isohashi F, Otani K, Suzuki M, Fujii T, Yoshii T, Mitani K, Yasui T, Cho H, Tomita Y, Morii E, Teshima T, Ogawa K, Inohara H.
    • Journal Title

      Int J Clin Oncol.

      Volume: - Issue: 6 Pages: 640-648

    • DOI

      10.1007/s10147-019-01394-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of Enterococcus infection in the pathogenesis of chronic pancreatitis and cancer2018

    • Author(s)
      Maekawa Tomohiro、Fukaya Risako、Takamatsu Shinji、Itoyama Saki、Fukuoka Tomoya、Yamada Makoto、Hata Tomoki、Nagaoka Satoshi、Kawamoto Koichi、Eguchi Hidetoshi、Murata Kohei、Kumada Takashi、Ito Toshifumi、Tanemura Masahiro、Fujimoto Kahoko、Tomita Yasuhiko、Tobe Toru、Kamada Yoshihiro、Miyoshi Eiji
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 506 Issue: 4 Pages: 962-969

    • DOI

      10.1016/j.bbrc.2018.10.169

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Promotion of malignant phenotype after disruption of the three-dimensional structure of cultured spheroids from colorectal cancer.2018

    • Author(s)
      Piulats JM, Kondo J, Endo H, Ono H, Hagihara T, Okuyama H, Nishizawa Y, Tomita Y, Ohue M, Okita K, Oyama H, Bono H, Masuko T, Inoue M.
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 22 Pages: 15968-15983

    • DOI

      10.18632/oncotarget.24641

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] mpact of electrosurgical unit mode on post esophageal endoscopic submucosal dissection stricture in an in vivo porcine model.2018

    • Author(s)
      Tonai Y, Ishihara R, Yamasaki Y, Arao M, Iwatsubo T, Kato M, Suzuki S, Hamada K, Shichijo S, Matsuura N, Kanesaka T, Nakahira H, Yamamoto S, Akasaka T, Hanaoka N, Takeuchi Y, Higashino K, Uedo N, Tomita Y, Iishi H.
    • Journal Title

      Endosc Int Open.

      Volume: 6 Issue: 03 Pages: E376-E381

    • DOI

      10.1055/s-0043-122883

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth.2016

    • Author(s)
      Hayashi Y, Tsujii M, Kodama T, Akasaka T, Kondo J, Hikita H, Inoue T, Tsujii Y, Maekawa A, Yoshii S, Shinzaki S, Watabe K, Tomita Y, Inoue M, Tatsumi T, Iijima H, Takehara T.
    • Journal Title

      Carcinogenesis.

      Volume: 37 Issue: 10 Pages: 972-984

    • DOI

      10.1093/carcin/bgw085

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pancreatic juice cytology as sensitive test for detecting pancreatic malignancy in intraductal papillary mucinous neoplasm of the pancreas without mural nodule.2016

    • Author(s)
      Kawada N., Tomita Y., et al.
    • Journal Title

      Pancreatology

      Volume: 16(5) Issue: 5 Pages: 853-8

    • DOI

      10.1016/j.pan.2016.07.011

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical relevance of aberrant polypoid nodule scar after endoscopic submucosal dissection.2016

    • Author(s)
      Arantes V, Uedo N, Pedrosa MS, Tomita Y.
    • Journal Title

      World J Gastrointest Endosc.

      Volume: 8 Issue: 17 Pages: 628-634

    • DOI

      10.4253/wjge.v8.i17.628

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Usefulness of dual phase 18F-FDG-PET/CT for diagnosing small pancreatic tumors.2015

    • Author(s)
      Kawada N, Uehara H, Hosoki T, Takami M, Shiroeda H, Arisawa T, Tomita Y
    • Journal Title

      Pancreas

      Volume: 44 Issue: 4 Pages: 655-659

    • DOI

      10.1097/mpa.0000000000000313

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optimal number of needle passes in endoscopic ultrasound-guided fine needle aspiration for pancreatic lesions.2015

    • Author(s)
      Uehara H, Sueyoshi H, Takada R, Fukutake N, Katayama K, Ashida R, Ioka T, Takenaka A, Nagata S, Tomita Y.
    • Journal Title

      Pancreatology

      Volume: 15 Issue: 6 Pages: 392-396

    • DOI

      10.1016/j.pan.2015.08.004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dynamic Change in p63 Protein Expression during Implantation of Urothelial Cancer Clusters.2015

    • Author(s)
      Yoshida T, Okuyama H, Nakayama M, Endo H, Tomita Y, Nonomura N, Nishimura K, Inoue M.
    • Journal Title

      Neoplasia

      Volume: 17 Issue: 7 Pages: 574-585

    • DOI

      10.1016/j.neo.2015.07.004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] GGNを呈する肺腺癌に対するEGFR遺伝子変異と変異型およびリン酸化EGFR抗体による免疫染色解析2015

    • Author(s)
      熊谷 融, 冨田 裕彦, 木村 円花, 井上 貴子, 内田 純二, 西野 和美, 今村 文生
    • Organizer
      第56回日本肺癌学会
    • Place of Presentation
      横浜市
    • Year and Date
      2015-11-26
    • Related Report
      2015 Research-status Report
  • [Book] Cellprep一般細胞診アトラス2016

    • Author(s)
      冨田裕彦、竹中明美
    • Total Pages
      108
    • Publisher
      学際企画
    • Related Report
      2015 Research-status Report
  • [Book] Cellprep子宮頚部細胞診アトラス2015

    • Author(s)
      冨田裕彦、竹中明美
    • Total Pages
      86
    • Publisher
      学際企画
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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