| Project/Area Number |
15K08391
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | International University of Health and Welfare (2017-2018)
Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2015-2016) |
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Principal Investigator |
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| Research Collaborator |
Kubo Chiaki 大阪府立国際がんセンター, 病理・細胞診断科, 医員
Kitamura Masanori 大阪府立国際がんセンター, 病理・細胞診断科, 医員
Kotani Syohta 大阪府立成人病センター, 病理・細胞診断科, 研究員
Kishida Mioka 大阪府立国際がんセンター, 病理・細胞診断科, 医師
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | VCP / UBL4A / STAT3 / 臨床病理学的検討 / NFκB / STAS3 / GdX |
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| Outline of Final Research Achievements |
This study was designed to clarify the correlation between VCP and UBL4A in the STAT3 signaling pathway. In the first step, analysis using cell lines was not reproductive. Then, analysis using gene-modified mouse was planned. VCP-conditional KO mouse, VCP-transgenic mouse were successfully made. In addition, clinic-pathologic analysis on cancer development and metastasis was performed.
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| Academic Significance and Societal Importance of the Research Achievements |
VCPとUBL4Aの関連の検討は、モデルマウスの作製が必須と考え、作製には成功したが、研究期間内では、さらなる検討には至らなかった。後続の検討を行い成果を発表していきたい。
そのほか、がんに関する臨床病理学的検討を行い、乳がんのリンパ節転移を検出するOne-step nucleic acid amplification assayの有用性を明らかにし、中咽頭扁平上皮癌のHPV statusと治療効果の関係、食道腺癌のリンパ節転移に関与す因子、EGFR遺伝子変異を伴わない肺腺癌の進展に関与する因子を明らかにした。
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