| Project/Area Number |
15K08406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
守山 正胤 大分大学, 医学部, 教授 (90239707)
平下 有香 大分大学, 医学部, 医員 (70771955)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 胃癌 / DDX27 / シグナル伝達 / 分子標的 / 進行 |
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| Outline of Final Research Achievements |
Previously, we reported that DDX27 gene is amplified and overexpressed with the progress of gastric carcinogenesis. In this project, we aimed to determine whether DDX27 contributes to malignancy of gastric cancer. Before we started this project, we found that expression of DDX27 is related to colony formation of gastric cancer cells and patients' survival. In this project, we analyzed the impact of DDX27 knockdown on gastric cancer cells and found that 1)DDX27 contributes to tumor formation in vivo, 2)DDX27 regulates cell cycle of gastric cancer cells and 3)DDX27 regulates phosphorylation of Akt. These results contribute to establish a novel molecular targeted therapy in gastric cancer. We reported these data in American Journal of Cancer Research.
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