Analysis of cancer stem cell phenotype of apoptosis-resistant breast cancer cells
| Project/Area Number |
15K08411
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
Takahashi Rei 同志社女子大学, 薬学部, 教授 (60144565)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 乳癌 / 癌幹細胞 / アポトーシス / ALDH / 細胞分化 / 前駆細胞 / 分化誘導 / p53 |
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| Outline of Final Research Achievements |
The subpopulations of the human breast cancer cell line HCC1937 that exhibit resistance to p53-induced apoptosis showed similarities with the breast cancer stem cells in the expression profiles of some breast cancer stem cell-related markers ALDH1A3, Sox-2, and CD44. These apoptosis-resistant cells showed the ability of not only apoptosis-resistance but also reconstruction of cancer cell hierarchy, epithelial-mesenchymal transition, and ductal differentiation. These findings may provide basis of cancer stem cell properties and aid to develop a new therapeutic measure to cancer.
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Report
(4 results)
Research Products
(12 results)
