| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The subpopulations of the human breast cancer cell line HCC1937 that exhibit resistance to p53-induced apoptosis showed similarities with the breast cancer stem cells in the expression profiles of some breast cancer stem cell-related markers ALDH1A3, Sox-2, and CD44. These apoptosis-resistant cells showed the ability of not only apoptosis-resistance but also reconstruction of cancer cell hierarchy, epithelial-mesenchymal transition, and ductal differentiation. These findings may provide basis of cancer stem cell properties and aid to develop a new therapeutic measure to cancer.
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