| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Recent advantages of transcriptome analyses revealed that non-coding RNAs, especially long non-coding (lnc) RNAs, are transcribed across genome and involved in various aspects of biological processes. I have identified a novel lncRNA that positively regulates inflammatory cytokine expression and named LASC. LASC is required for the expression of inflammatory cytokines such as IL-6 and GM-CSF. Recruitment of transcription factor NF-kB was strongly reduced in LASC deficient cells, suggesting that LASC could regulate inflammatory cytokine expression at transcriptional level. In order to clarify the role of LASC in inflammation in vivo, LASC knockout mice were generated by genome editing technology and showed resistance to endotoxin shock.
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