Analysis of dendritic cell functions in peripheral tissues
| Project/Area Number |
15K08431
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Hemmi Hiroaki 和歌山県立医科大学, 先端医学研究所, 准教授 (20451924)
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| Research Collaborator |
FUKUDA Yuri
HATTORI Ikuko
NISHIYAMA Naoko
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 樹状細部 / 免疫応答 / 免疫寛容 / 樹状細胞 / 遺伝子改変マウス |
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| Outline of Final Research Achievements |
Dendritic cells (DCs), professional antigen presenting cells, consist of several subsets with specialized functions. However, it is still largely unclear how DC subsets regulate immunological homeostasis in peripheral tissues. In this study, functions of a DC subset expressing a chemokine receptor, XCR1, were analyzed. This subset has a high ability to cross-present antigens to naive CD8 T cells. In XCR1+ DC constitutively ablated mice, intestinal T cells including intraepithelial lymphocytes were deceased as compared with control mice, while splenic T cells were not affected. In control mice given antigens orally, antigen-specific antibody responses were suppressed (oral tolerance). However, if XCR1+ DC was inducibly and transiently ablated when the antigen was orally administered, antigen-specific antibody responses were not suppressed, suggesting that XCR1+ DC is crucial for induction of oral tolerance. Thus, XCR1+ DC plays important role in the intestine on immune environments.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis.2016
Author(s)
Ohta T, Sugiyama M, Hemmi H, Yamazaki C, Okura S, Sasaki I, Fukuda Y, Orimo T, Ishii KJ, Hoshino K, Ginhoux F, Kaisho T.
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Journal Title
Scientific Reports
Volume: 162
Issue: 1
Pages: 23505-23505
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] The critical role of dendritic cell subset in expanding Foxp3+ regulatory T cells in the murine skin after ultraviolet B exposure.2017
Author(s)
Sayuri Yamazaki, Akiko Nishioka, Saori Kasuya, Mizuyu Odanaka, Hiroaki Hemmi, Masaki Imai, Dieter Riethmacher, Tsuneyasu Kaisho, Naganari Ohkurah, Shimon Sakaguchi, Akimichi Morita.
Organizer
15th International Workshop on Langerhans Cells
Related Report
Int'l Joint Research
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[Presentation] ケモカインXCL1を用いたがんペプチドワクチン療法の開発2016
Author(s)
水本有紀, 勝田将裕, 宮澤基樹, 北畑裕司, 宮本篤, 中森幹人, 松田健司, 尾島敏康, 早田啓治, 北谷純也, 邊見弘明, 改正恒康, 山上裕機.
Organizer
第29回 日本バイオセラピィ学会学術集会総会
Place of Presentation
久留米シティプラザ（福岡県久留米市）
Year and Date
2016-12-01
Related Report
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