| Project/Area Number |
15K08431
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Hemmi Hiroaki 和歌山県立医科大学, 先端医学研究所, 准教授 (20451924)
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| Research Collaborator |
FUKUDA Yuri
HATTORI Ikuko
NISHIYAMA Naoko
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 樹状細部 / 免疫応答 / 免疫寛容 / 樹状細胞 / 遺伝子改変マウス |
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| Outline of Final Research Achievements |
Dendritic cells (DCs), professional antigen presenting cells, consist of several subsets with specialized functions. However, it is still largely unclear how DC subsets regulate immunological homeostasis in peripheral tissues. In this study, functions of a DC subset expressing a chemokine receptor, XCR1, were analyzed. This subset has a high ability to cross-present antigens to naive CD8 T cells. In XCR1+ DC constitutively ablated mice, intestinal T cells including intraepithelial lymphocytes were deceased as compared with control mice, while splenic T cells were not affected. In control mice given antigens orally, antigen-specific antibody responses were suppressed (oral tolerance). However, if XCR1+ DC was inducibly and transiently ablated when the antigen was orally administered, antigen-specific antibody responses were not suppressed, suggesting that XCR1+ DC is crucial for induction of oral tolerance. Thus, XCR1+ DC plays important role in the intestine on immune environments.
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