Osteonecrosis of the femoral head in childhood

• Project/Area Number: 15K08437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Tenri University
• Principal Investigator: Kamiya Nobuhiro 天理大学, 体育学部, 教授 (50735876)
• Research Collaborator: Kim Harry Texas Scottish Rite Hospital, Professor
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 骨壊死 / 小児 / インターロイキン６ / 大腿骨頭 / ペルテス病 / 動物モデル / 骨吸収 / 骨形成 / ブタ / ネズミ / 炎症性起因物質 / ヒト / モデル

Outline of Final Research Achievements

This study focuses on the pediatric osteonecrosis of the femoral head. In order to prevent a collapse of the femoral head, there is a strict limitation of school activity and daily life for children with this disease. Although this disease was first reported over 100 years ago, it still takes several years for the initial treatment. We found that interleukin-6 is abundantly expressed in the hip joint effusion and that some garbage from the dead cells can induce interleukin-6 as a disease mechanism. We think that inhibition of interleukin-6 can improve the disease condition especially for preventing the collapse.

Research Products

• [Int'l Joint Research] Ｔｅｘａｓ Ｓｃｏｔｔｉｓｈ Ｒｉｔｅ Ｈｏｓｐｉｔａｌ(米国)
• [Int'l Joint Research] Ｔｅｘａｓ Ｓｃｏｔｔｉｓｈ Ｒｉｔｅ Ｈｏｓｐｉｔａｌ(米国)
• [Journal Article] :小児関節疾患における生化学的アプローチ（ペルテス病を中心に） (2017)
  • Author(s): 神谷 宣広
  • Journal Title: Ｂｏｎｅ Ｊｏｉｎｔ Ｎｅｒｖｅ Volume: 27 Pages: 557-562
• [Journal Article] HIF-1-Dependent IL-6 Activation in Articular Chondrocytes Initiating Synovitis in Femoral Head Ischemic Osteonecrosis (2016)
  • Author(s): Yamaguchi R, Kamiya N, Adapala NS, Drissi H, Kim HK
  • Journal Title: J Bone Joint Surg Am Volume: 98 Issue: 13 Pages: 1122-1131
  • DOI: 10.2106/jbjs.15.01209
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] In Vivo Monitoring of Activated Macrophages and Neutrophils in Response to Ischemic Osteonecrosis in a Mouse Model (2016)
  • Author(s): Phipps, M. C., Huang, Y., Yamaguchi, R., Kamiya, N., Adapala, N. S., Tang, L., Kim, H. K.
  • Journal Title: J Orthop Res Volume: 34（２） Issue: 2 Pages: 307-313
  • DOI: 10.1002/jor.22952
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of a Mouse Model of Ischemic Osteonecrosis (2015)
  • Author(s): Kamiya, N., Yamaguchi, R., Aruwajoye, O., Adapala, N.S., Kim, H.K.
  • Journal Title: Clinical Orthopaedics and Related Research Volume: 473(4) Issue: 4 Pages: 1486-1498
  • DOI: 10.1007/s11999-015-4172-6
  • Peer Reviewed / Open Access
• [Journal Article] Legg-Calvé-Perthes Disease Produces Chronic Hip Synovitis and Elevation of Interleukin-6 in the Synovial Fluid (2015)
  • Author(s): Kamiya, N., Yamaguchi, R., Adapala, N.S., Chen. E., Neal, D., O’Brien, J., Thovesona, A., Gudmundssona, P., Brabhama, C., Aruwajoye, O., Drissi, H., Kim H.K.
  • Journal Title: Journal of Bone and Mineral Research Volume: in press Issue: 6 Pages: 1009-1013
  • DOI: 10.1002/jbmr.2435
  • Peer Reviewed
• [Journal Article] ぺルテス病の分子レベルでの病態解析 (2015)
  • Author(s): 神谷宣広
  • Journal Title: 近畿小児整形外科 Volume: 28 Pages: 52-53
• [Presentation] 小児整形外科における基礎研究（ペルテス病を中心に） (2018)
  • Author(s): 神谷 宣広
  • Organizer: 小児整形外科学会
  • Invited
• [Presentation] A report of 2015 KPOS-TPOS-JPOA Exchange Fellowship in Korea (2016)
  • Author(s): KAMIYA N
  • Organizer: The 27th Annual Meeting of the Japanese Pediatric Orthopaedic Association
  • Place of Presentation: Miyagi, Japan
  • Year and Date: 2016-12-01
  • Int'l Joint Research
• [Presentation] Basic research of Perthes disease (2016)
  • Author(s): KAMIYA N
  • Organizer: The 27th Annual Meeting of the Japanese Pediatric Orthopaedic Association
  • Place of Presentation: Miyagi, Japan
  • Year and Date: 2016-12-01
  • Int'l Joint Research / Invited
• [Presentation] HIF-1-dependent IL-6 activation in articular chondrocytes as a mechanism for the initiation of hip synovitis following ischemic osteonecrosis of the femoral head (2016)
  • Author(s): Yamaguchi R, Kamiya N
  • Organizer: The 27th Annual Meeting of the Japanese Pediatric Orthopaedic Association
  • Place of Presentation: Miyagi, Japan
  • Year and Date: 2016-12-01
  • Int'l Joint Research
• [Presentation] Basic research of Perthes disease (2016)
  • Author(s): KAMIYA N
  • Organizer: The annual meeting of Korean Paediatric Orthopaedic Society
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-06-03
  • Int'l Joint Research / Invited
• [Presentation] My basic research in pediatric orthopaedics (2016)
  • Author(s): KAMIYA N
  • Organizer: Seoul National University Children's Hospital
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-06-01
  • Invited
• [Presentation] Legg-Calvé-Perthes Disease Produces Chronic Hip Synovitis and Elevation of Interleukin-6 in the Synovial Fluid (2015)
  • Author(s): Kamiya, N.
  • Organizer: The 26th Annual Meeting of the Japanese Pediatric Orthopaedic Association
  • Place of Presentation: Ｇｉｆｕ
  • Year and Date: 2015-12-04
  • Int'l Joint Research
• [Presentation] 私の整形外科基礎研究 (2015)
  • Author(s): 神谷宣広
  • Organizer: 第１２回ＯＢＭＭＧ
  • Place of Presentation: 東京
  • Year and Date: 2015-07-25
  • Invited
• [Presentation] 小児大腿骨頭壊死症に対する基礎研究（ペルテス病の分子レベルでの病態解析） (2015)
  • Author(s): 神谷宣広
  • Organizer: 第54回日本小児股関節研究会
  • Place of Presentation: 東京
  • Year and Date: 2015-06-26