| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The pathology of malaria is caused by asexual stage parasite proliferation in erythrocytes. This amplification cycle involves merozoite release from infected erythrocytes followed by invasion of and growth within new erythrocytes. The essential steps of erythrocyte invasion are mediated by molecular mechanisms which are potential targets for the prevention and treatment of malaria. In this study, we generate conditional apical membrane antigen 1 (AMA1) knockout Plasmodium falciparum parasites and show that AMA1 is not involved in erythrocyte deformation immediately prior to erythrocyte internalisation, but is associated with the formation of the tight junction between the merozoite and the erythrocyte.
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