Role of IFNGR1 in pregnant mice infected with Plasmodium berghei
| Project/Area Number |
15K08451
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
新倉 保 杏林大学, 医学部, 学内講師 (30407019)
井上 信一 杏林大学, 医学部, 学内講師 (20466030)
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| Research Collaborator |
YOKOTA NATSUKI
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | マラリア / 妊娠 / 重症化 / 胎盤 / 接着 / 炎症 / IFNGR1 / 生体イメージング / 脂肪組織 / 比較プロテオーム / マラリア原虫 / ルシフェラーゼ / IFN-γ / IFN-γR1 / 組織傷害 / 胎児 |
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| Outline of Final Research Achievements |
Malaria during pregnancy is a major public health problem in malaria-endemic regions. Placental malaria has been reported to be correlated with adverse pregnancy outcomes such as fetal growth restriction, stillbirth, premature delivery. However, the immunopathogenesis of placental pathology during severe malaria is poorly understood. Recently, we found that fetal mortality in IFN-γ receptor 1-deficient (IFNGR1-KO) C57BL/6J mice infected with rodent malaria parasites, Plasmodium berghei NK65 (PbNK65) was much less than that in infected wild type (WT) mice. Placental pathology was also improved in infected IFNGR1-KO mice. In contrast, bioluminescence imaging showed that parasite accumulation in the placentas of IFNGR1-KO pregnant mice infected with luciferase-expressing PbNK65 was comparable to that in infected WT mice. These findings suggest that IFNGR1 signaling plays a pivotal role in placental pathology and subsequent adverse pregnancy outcomes during severe malaria.
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Report
(4 results)
Research Products
(74 results)
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[Journal Article] Expansion and differentiation of hematopoietic stem cells by IL-27 into myeloid progenitors to control infection2016
Author(s)
Furusawa J-I, Mizoguchi I, Chiba Y, Hisada M, Kobayashi F, Yoshida H, Nakae S, Tshuchida A, Matsumoto T, Ema H, Mizuguchi J, Yoshimoto T
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Journal Title
PLoS Pathogen
Volume: 12
Issue: 3
Pages: e1005507-e1005507
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Experimental Lung Research2015
Author(s)
Manabu Higaki, Hiroo Wada, Shin-ichiro Mikura, Tetsuo Yasutake, Masuo Nakamura, Mamoru Niikura, Fumie Kobayashi, Hiroshi Kamma, Shigeru Kamiya, Kazuhiro Ito, Peter Barnes, Hajime Goto, Hajime Takizawa
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Journal Title
IL-10 modulates pulmonary neutrophilic inflammation induced by cigarette smoke exposure
Volume: 41
Issue: 10
Pages: 525-534
DOI
Related Report
Peer Reviewed
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[Presentation] Current status of imported malaria in Japan.2017
Author(s)
Fumie Kobayashi, Mamoru Niikura, Shin-Ichi Inoue, Hiroko Asahi
Organizer
Scientific Symposium of Japan-India Research Exchange Projects within “Strategic International Research Cooperative Program (SICP)”
Place of Presentation
札幌
Related Report
Int'l Joint Research
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[Presentation] Plasmodium falciparum ガメトサイト形成に伴って特異的に発現される分子の網羅的解析2016
Author(s)
朝日博子, 救仁郷圭祐, 竹田美香, 矢幡一英, 井上信一, 新倉 保, Indah S. Tantular, Fumihiko Kawamoto, 中澤秀介, 小林富美惠, 金子 修, 鈴木 穣
Organizer
第85回日本寄生虫学会大会
Place of Presentation
宮崎
Year and Date
2016-03-19
Related Report
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[Presentation] IL-17A/F遺伝子欠損マウスは長期喫煙曝露による気腔開大が抑制される （Interleukin-17A/F regulates MMP-9 expression in the lung of mice after inhalation of cigarette smoke.）2015
Author(s)
中村 益夫, 和田 裕雄, 佐田 充, 乾 俊哉, 中本 啓太郎, 檜垣 学, 宮東 昭彦, 井上 信一, 花輪 智子, 小林 富美恵, 菅間 博, 滝澤 始
Organizer
第38回日本分子生物学会年会/第88回日本生化学会大会
Place of Presentation
神戸
Year and Date
2015-12-01
Related Report
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