| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
To clarify the role of autophagy in antibacterial host defense, we investigated the regulation mechanism of autophagy mediated by reactive persulfide species and protein S-guanylation, and effects of reactive persulfides produced by bacteria. S-Guanylation of bacteria in infected-host cells was found to be involved in bacterial killing by autophagy in host cells, and reactive persulfides produced by bacteria were suggested to suppress S-guanylation-mediated autophagy induction and contribute to its escape from defense mechanism of host cells.
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