Development of a novel Shiga toxin inhibitor that targeting of intracellular transport of the toxin
| Project/Area Number |
15K08480
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Doshisha University |
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Principal Investigator |
Takahashi Miho 同志社大学, 生命医科学部, 助教 (00446569)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 志賀毒素 / 細胞内小胞輸送 / ペプチド / 阻害剤 / ペプチドライブラリー / 腸管出血性大腸菌 / 感染症 / キナーゼ基質アレイ / 小胞輸送 / Stx阻害ペプチド |
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| Outline of Final Research Achievements |
We synthesized substrate peptides of various kinases on a slide glass and using this, we analyzed the activities of kinases stimulated by Stx1a in the presence or absence of Stx inhibitors (MMA-tet, FRA-tet).We established a new multivalent peptide library screening by using tetravalent peptides synthesized on a cellulose membrane.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy2018
Author(s)
Shimasaki K, Watanabe-Takahashi M, Umeda M, Funamoto S, Saito Y, Noguchi N, Kumagai K, Hanada K, Tsukahara F, Maru Y, Shibata N, Naito M, Nishikawa K.
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Journal Title
Genes to Cells
Volume: 23
Issue: 1
Pages: 22-34
DOI
Related Report
Peer Reviewed / Open Access
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