Escaping mechanism of emerging relapsing fever pathogen, Borrelia miyamotoi, from complement pathway

Research Project

Project/Area Number	15K08487
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Bacteriology (including mycology)
Research Institution	National Institute of Infectious Diseases
Principal Investigator	Kawabata Hiroki 国立感染症研究所, 細菌第一部, 室長 (60280765)
Research Collaborator	Takano Ai Hayashi Tetsuya Kumagai Yumi Sato Kozue
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	ボレリア / 新興回帰熱 / 血清感受性 / 自然免疫 / 血清耐性 / Borrelia miyamotoi / Borrelia garinii
Outline of Final Research Achievements	A experimental system to examine the serum susceptibility of Borreliae has been established in this study. Using this system, we obtained Borrelia transforms which were introduced with outer surface protein encoding gene of B. miyamotoi, and were examined its human serum susceptibility. As a result, I found several genes from B. miyamotoi are independently contributing its serum susceptibility.

Report

(4 results)