Escaping mechanism of emerging relapsing fever pathogen, Borrelia miyamotoi, from complement pathway
| Project/Area Number |
15K08487
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
Kawabata Hiroki 国立感染症研究所, 細菌第一部, 室長 (60280765)
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| Research Collaborator |
Takano Ai
Hayashi Tetsuya
Kumagai Yumi
Sato Kozue
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ボレリア / 新興回帰熱 / 血清感受性 / 自然免疫 / 血清耐性 / Borrelia miyamotoi / Borrelia garinii |
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| Outline of Final Research Achievements |
A experimental system to examine the serum susceptibility of Borreliae has been established in this study. Using this system, we obtained Borrelia transforms which were introduced with outer surface protein encoding gene of B. miyamotoi, and were examined its human serum susceptibility. As a result, I found several genes from B. miyamotoi are independently contributing its serum susceptibility.
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Report
(4 results)
Research Products
(1 results)
