| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
Molecular Mechanisms for the inhibition of infectious hepatitis C virus particle formation by thromboxane A2 synthase inhibitor, Oxagrel, was examined in detail by several techniques. Microarray and CAGE analyses have showed no informative result. Metabolite study, however, showed that the reduction of hexanoic acid (HA), a fatty acid with pentatonic carbon chain, was caused in the cells treated with Oxagrel. The contribution of HA to the infectious HCV particle formation was not cleared yet. It seemed to be a novel finding that the amount of HA in the cells was changed by TXAS inhibitor.
|
