| Project/Area Number |
15K08500
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Gifu University (2016-2017)
Wakayama Medical University (2015) |
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Principal Investigator |
GOTO Hideo 岐阜大学, 応用生物科学部, 研究員 (50323639)
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 直人 岐阜大学, 応用生物科学部, 准教授 (20334922)
太田 圭介 和歌山県立医科大学, 医学部, 助教 (90625071)
松本 祐介 和歌山県立医科大学, 医学部, 助教 (00735912)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ウイルス / ウイルスの干渉 / 受容体破壊 / 干渉現象 / センダイウイルス / 重感染 / シアル酸 |
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| Outline of Final Research Achievements |
To develop a novel strategy to control virus infection, we studied on a mechanism of viral interference. Interference of Sendai virus infection was established at an early stage of infection such as attachment or penetration. Additionally, viral interference was dependent on the HN protein expression that releases sialic acids (a receptor molecule for Sendai virus) by the sialidase activity and decrease of sialic acid molecules on the cell surface. Rabies virus also showed viral interference at an early stage of infection in spite of lack of a receptor destruction factor similar to that of the HN protein.
From these results, we concluded that a receptor destruction by virus infection is one of a major factor for viral interference.
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