| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We revealed gene regulatory mechanisms for the development of intestinal intraepithelial lymphocytes (IELs) expressing CD8alpha homodimers and newly discovered innate lymphoid cells (ILC), which play crucial roles in the homeostasis in the gut and are gathering much interests as to how they are involved in the pathogenesis of gastroenterological disorders. Thus, we showed that the transcription factor interferon regulatory factor 2 (IRF-2) was required for functional maturation of thymic precursors for IELs and for the generation of common progenitors in the bone marrow for ILC1, ILC2 and ILC3 but not lymphoid tissue inducer-like cells. To further clarify how IRF-2 functions in these processes will provide us with deeper understanding of the mechanisms underlying the establishment of mucosal immune system.
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