Theoretical and experimental analyses to reveal the mechanisms of immune regulation
| Project/Area Number |
15K08530
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | 医療法人徳洲会野崎徳洲会病院(附属研究所) (2017)
Osaka University (2015-2016) |
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Principal Investigator |
Yamaguchi Tomoyuki 医療法人徳洲会野崎徳洲会病院(附属研究所), 研究所, 主任研究員 (80402791)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 制御性T細胞 / 数理モデル / 不安定性 / ゆらぎ / 免疫チェックポイン / 免疫制御モデル / 多様性 / 選択的増殖 / 免疫寛容 |
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| Outline of Final Research Achievements |
Self-reactive regulatory T cells are essential to maintain the immune tolerance. In this study, I searched which processes in immune response should be controlled by regulatory T cells using simulations and mathematical modeling of T cell immune response. The results indicate that simple reduction of proliferation probability of T cells by regulatory T cells is not sufficient for the robust tolerance. Augmentation of interaction between T cells and antigen-presenting cells is essential to stabilize the tolerance. Further, the theoretical prediction provides novel perturbations to enhance immune responses in autoimmune diabetes mice model and in allogeneic T cell response. Thus, I propose a potential landscape model in immune regulation that stable tolerance proceeds to immune response or proliferation of specific T cells through transient fluctuating states by controlling the total amount of interaction between antigen-presenting cells and T cells.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses.2017
Author(s)
Sasaki, N., T. Yamashita, K. Kasahara, A. Fukunaga, T. Yamaguchi, T. Emoto, K. Yodoi, T. Matsumoto, K. Nakajima, T. Kita, M. Takeda, T. Mizoguchi, T. Hayashi, Y. Sasaki, M. Hatakeyama, K. Taguchi, K. Washio, S. Sakaguchi, B. Malissen, C. Nishigori, and K.I. Hirata
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 37(1)
Issue: 1
Pages: 66-74
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Overexpression of Cytotoxic T-Lymphocyte–Associated Antigen-4 Prevents Atherosclerosis in Mice2016
Author(s)
Takuya Matsumoto, Naoto Sasaki, Tomoya Yamashita, Takuo Emoto, Kazuyuki Kasahara, Taiji Mizoguchi, Tomohiro Hayashi, Keiko Yodoi, Naoki kitano, Takashi Saito, Tomoyuki Yamaguchi, and Ken-ichi Hirata
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 36
Issue: 6
Pages: 1141-51
DOI
Related Report
Peer Reviewed / Open Access
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