Regulation of the immunological function by the CD47-SIRP alpha signaling system
| Project/Area Number |
15K08532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 樹状細胞 / ストローマ細胞 / SIRPα / CD47 / 免疫学 |
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| Outline of Final Research Achievements |
We have here investigated the regulatory mechanism of the immune system, especially of dendritic cell function by the CD47-SIRPα signaling system. We have shown that both SIRPα and CD47 on dendritic cells regulate homeostasis of SIRPα+ dendritic cells in lymphoid organs. Moreover, these molecules regulate homeostasis of stromal cells in the spleen through the production of TNF receptor ligands by dendritic cells. Furthermore, we have established a mouse model to characterize human dendritic cells in vivo using humanized mice in the immune system.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness.2017
Author(s)
Takizawa H, Fritsch K, Kovtonyuk LV, Saito Y, Yakkala C, Jacobs K, Ahuja AK, Lopes M, Hausmann A, Hardt WD, Gomariz A, Nombela-Arrieta C, Manz MG.
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Journal Title
Cell Stem Cell
Volume: 21
Issue: 2
Pages: 225-240
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy.2017
Author(s)
Yanagita T, Murata Y, Tanaka D, Motegi S, Arai E, Daniwijaya EW, Hazama D, Washio K, Saito Y, Kotani T, Ohnishi H, Oldenborg PA, Verjan Garcia N, Miyasaka M, Ishikawa O, Kanai Y, Komori T, Matozaki T.
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Journal Title
JCI Insight
Volume: 2
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Ellegast JM, Rauch PJ, Kovtonyuk LV, Muller R, Wagner U, Saito Y, Wildner-Verhey van Wijk N, Fritz C, Rafiei A, Lysenko V, Dudkiewicz E, Theocharides AP, Soldini D, Goede JS, Flavell RA, Manz MG.2016
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[Journal Article] Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs2015
Author(s)
Washio K, Kotani T, Saito Y, Respatika D, Murata Y, Kaneko Y, Okazawa H, Ohnishi H, Fukunaga A, Nishigori C, Matozaki T.
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Journal Title
Genes Cells
Volume: -
Issue: 6
Pages: 00-00
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium2015
Author(s)
Y Murata, T Kotani, Y Supriatna, Y Kitamura, S Imada, K Kawahara, M Nishio, EW Daniwijaya, H Sadakata, S Kusakari, M Mori, Y Kanazawa, Y Saito, K Okawa, M Takeda-Morishita, H Okazawa, H Ohnishi, T Azuma, A Suzuki, T Matozaki
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Journal Title
Proc Natl Acad Sci U S A
Volume: 112
Issue: 31
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] SIRPα+ dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen2017
Author(s)
Yasuyuki Saito, Satomi Komori, Datu Respatika, Ken Washio, Takenori Kotani, Yoji Murata, Hiroshi Ohnishi, Katsuyuki Yui, Koji Yasutomo, Takashi Matozaki
Organizer
The 5th annual meeting of the international cytokine and interferon society, ICIS 2017
Related Report
Int'l Joint Research
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[Presentation] Essential role of SIRPα on dendritic cells in Homeostatic regulation of the secondary lymphoid organ2015
Author(s)
Datu Respatika, Yasuyuki Saito, Ken Washio, Satomi Komori, Takenori Kotani, Yoji Murata, Yoriaki Kaneko, Hideki Okazawa, Hiroshi Ohnishi, Atsushi Fukunaga, Chikako Nishigori, Takashi Matozaki
Organizer
2015University of Washington and Kobe University joint symposium 2015神戸大学・ワシントン大学国際合同シンポジウム
Place of Presentation
Seattle, USA(University of Washington)
Year and Date
2015-09-11
Related Report
Int'l Joint Research
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