Runx-mediated regulation of chemokine CCL5 for lung diseases
| Project/Area Number |
15K08535
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Institute of Physical and Chemical Research |
|---|
Principal Investigator |
Seo Wooseok 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 (40574116)
|
|---|
| Project Period (FY) |
2015-10-21 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | アレルギー / 免疫関連疾患 / 免疫関連病患 |
|---|
| Outline of Final Research Achievements |
CCL5 chemokine is related to the development of many inflammatory diseases. To understand how CCL5 is regulated, I have examined a knockout mouse of Runx/CBFβ transcription factor and discovered that CCL5 is hugely upregulated in the absence of Runx/CBFβ. This indicated that CCL5 is tightly regulated by Runx/CBFβ. By combining regular ChIP and novel enChIP assays, I discovered that CCL5 expression requires two separate enhancers depending on activation states. These enhancers are crucial for proper expression of CCL5 from T cells as well as T-cell immunity.
|
Report
(4 results)
Research Products
(11 results)
-
[Journal Article] Essential Roles of SATB1 in Specifying T Lymphocyte Subsets2017
Author(s)
Kakugawa Kiyokazu、Kojo Satoshi、Tanaka Hirokazu、Seo Wooseok、Endo Takaho A.、Kitagawa Yohko、Muroi Sawako、Tenno Mari、Yasmin Nighat、Kohwi Yoshinori、Sakaguchi Shimon、Kowhi-Shigematsu Terumi、Taniuchi Ichiro
-
Journal Title
Cell Rep
Volume: 19
Issue: 6
Pages: 1176-1188
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes.2017
Author(s)
Kojo S, Tanaka H, Endo TA, Muroi S, Liu Y, Seo W, Tenno M, Kakugawa K, Naoe Y, Nair K, Moro K, Katsuragi Y, Kanai A, Inaba T, Egawa T, Venkatesh B, Minoda A, Kominami R, Taniuchi I.
-
Journal Title
Nat Commun.
Volume: 8
Issue: 1
Pages: 702-702
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
